Education
1975-1981 M.D. Hadassah University Med. School, Jerusalem
1987-1990 Residency, Department of Internal Medicine, Hadassah University Hospital, Jerusalem
1991-1993 Postdoctoral fellowship in Virology; Cytomegalovirus, University of California San Diego
1994-1996 Clinical fellowship in Infectious Diseases, Hadassah University Hospital, Jerusalem
1998-1999 Visiting scientist, the field Cytomegalovirus, Stanford University School of Medicine
Employment and professional experience
2001- Head, Clinical Virology Unit; Hadassah University Hospital
1996- Senior physician; infectious diseases; Hadassah University Hospital
Research Activities
· Cytomegalovirus pathogenicity and diagnosis
· Diagnostic virology
· Antiviral drugs, antiviral drug resistance
· Cytomegalovirus UL97 kinase
· Respiratory virus epidemiology
Professional Society Membership and honors
· Israel Medical Association
· American Society for Microbiology
· Pan American Society for Clinical Virology
· Infectious Disease Society of Israel
· Israeli Society for Microbiology
· European Clinical Virology Society
· Abraham Cesis Faculty Award
· The Sapir Pais foundation award for medical research, 2002
· The Hadassah Women’s Zionist Organization award for Women’s Health Research 2002
· The Israeli Society for Microbiology Sarov award for excellence in Clinical Virology 2006
Publications – last 10 years
1. Steiner I, Wolf DG. Neuropathies associated with herpesvirus infections. In: Immunological diseases of the peripheral nerves. Kelly JJ, Latov N, Wokke JHJ (eds) 1998. Cambridge University Press, New York.
2. Wolf DG, Honigman A, Lazarovits J, Tavor E, Panet A. Characterization of the Human cytomegalovirus UL97 gene product as a virion-associated protein kinase. Arch Virol 1998; 143: 1223-32.
3. Wolf DG, Yaniv I, Honigman A, Kassis I, Schonfeld T, Ashkenazi S. Early emergence of ganciclovir-resistant human cytomegalovirus strains in children with primary combined immunodeficiency. J Infect Dis 1998; 178: 535-8.
4. Gural A, Gillis S, Gafanovich A, Israel Z, Wolf D, Pomeranz S, Ben-Yehuda D. Massive intracranial bleeding requiring emergency splenectomy in a patient with CMV-associated thrombocytopenia. Haemostasis. 1999; 28:250-5.
5. Wolf DG, Polacheck I, Block C, Sprung CL, Muggia -Sullam M, wolf YG, Oppenheim-Eden A, Rivkind A, Shapiro M. High rate of candidemia in patients sustaining injuries in a bomb blast at a marketplace: a possible environmental source. Clin Infect Dis 2000: 31:712-6.
6. Panigrahi S, Nagler A, Or R, Wolf DG, Slavin S, Shapira MY. Indolent aspergillus arthritis complicating fludarabine based non-myeloablative stem cell transplantation. Bone Marrow Transplant 2001; 27:659-61
7. Sarid R, Pizov G, Rubinger D, Bekenroth R, Friedlander MM, Schwarz F, Wolf DG. Detection of human herpes virus-8 DNA in kidney allografts prior to the development of kaposi’s sarcoma. Clin Infect Dis 2001; 32:1502-5
8. Wolf DG, Yaniv I, Ashkenazi S, Honigman A. Emergence of multiple human cytomegalovirus ganciclovir-resistant variants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency. Antimicrob Agents Chemother 2001; 45:593-5
9. Wolf DG, Tan Courcelle C, Prichard MN, Mocarski ES. Distinct and separate roles for herpesvirus-conserved UL97 kinase in cytomegalovirus DNA synthesis and encapsidation. Proc Natl Acad Sci 2001; 98:1895-1900
10. Chowers MY, Lang R, Nassar F, Ben-David D, Giladi M, Rubinshtein E, Itzhaki A, Mishal J, Siegman-Igra Y, Kitzes R, Pick N, Landau Z, Wolf D, Bin H, Mendelson E, Pitlik SD, Weinberger M.Clinical characteristics of the West Nile fever outbreak, Israel, 2000. Emerg Infect Dis 2001;7:675-8.
11. Wolf DG, Falk R, Hacham M, Theelen B, Boekhout T, Scorzetti G, Shapiro M, Block C, Salkin IF, Polacheck I. Multidrug-resistant Trichosporon asahii infection of nongranulocytopenic patients in three intensive care units. J Clin Microbiol 2001;39:4420-5
12. Shibolet O, Kalish Y, Wolf D, Pappo O, Laxer U, Berkman N, Shaham D, Ashur Y, Ilan Y. Exacerbation of pulmonary sarcoidosis after liver transplantation. J Clin Gastroenterol 2002; 35:356-8
13. Markel G, Wolf D, Hanna J, Gazit R, Goldman-Wohl D, Lavy Y, Yagel S, Mandelboim O. Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions. J Clin Invest 2002; 110:943-53
14. Wolf DG, Lurain NS, Zuckerman T , Hoffman R, Satinger J , Honigman A, Saleh N, Robert ES, Rowe JM , Kra-Oz Z. Emergence of late cytomegalovirus central nervous system disease in hematopoietic stem cell transplant recipients. Blood 2003;101:463-5
15. Falk R, Wolf DG, Shapiro M, Polacheck I.Multidrug-resistant trichosporon asahii isolates are susceptible to voriconazole. J Clin Microbiol 2003 ; 41:911.
16. Barozzi P, Luppi M, Facchetti F, Mecucci C, Alù M, Sarid R, Rasini V, Ravazzini L, Rossi E, Festa S, Crescenzi B, Wolf DG, Schulz TF, Torelli G. Post-transplant Kaposi’s sarcoma originates from the seeding of donor-derived progenitors. Nat Med. 2003;9:554-61.
17. Shibolet O, Ilan Y, Kalish Y, Safadi R, Ashur Y, Eid A, Shouval D, Wolf DG. Late Cytomegalovirus infection occurring two or more years following liver transplantation: a report of 7 cases and review of the literature. Transplantation Proc. 2003:35:663-4.
18. Schattner A, Halperin D, Wolf D, Zimhony O. Enteroviruses and sudden deafness. CMAJ. 2003;168:1421-3.
19. Shibolet O, Ilan Y, Kalish Y, Safadi R, Ashur Y, Eid A, Shouval D, Wolf D. Late Cytomegalovirus disease following liver transplantation. Transplant Int. 2003;16:861-5..
20. Wolf DG, Zakay-Rones Z, Fadeela A, Greenberg D, Dagan R. High seroprevalence of human metapneumovirus among young children in Israel. J Infect Dis. 2003;188:1865-7.
21. Meirovitz A, Gotsman I, Liling M, Fridlender Z, Wolf DG. Osteomyelitis of the pubis after strenuous exercise-a case report. J Bone Joint Surg Am. 2004;86-A:1057-60
22. Elazary AS, Lador N, Shauer A, Meir K, Pollak A, Wolf DG, Raz I, Leitersdorf E, Mevorach D. Tongue necrosis and pericarditis. Lancet. 2004 ;363:948.
23. Avidor B, Efrat G, Weinberg M, Kra-oz Z, Satinger J, Mitrani-Rosenbaum S, Yaron Y, Shulman L, Tepperberg-Oikawa M, Wolf D, Berger SA, Lipitz S, Mendelson E, Giladi M. Insight into the intrinsic sensitivity of the PCR assay used to detect CMV infection in amniotic fluid specimens. J Clin Virol. 2004;29:260-70.
24. Wolf DG, Rekhtman D, Kerem E, Hay A, Mador N, Greenbaum E, Dorozhko M, Gregory V, Lin YP. Zakay-Rones Z. A Summer Outbreak of Influenza A Virus Among Young Children. Clin Infect Dis. 2004 ;39:595-7.
25. Bitan M, Or R, Shapira MY, Mador N, Resnick IB, Saleh N, Weinberger KM, Samuel S, Schechter E, Slavin S, Wolf DG. Early-Onset Guillain-Barre' Syndrome Associated with Epstein-Barr Virus Reactivation Post Nonmyeloablative Stem Cell Transplantation. Clin infect Dis. 2004;39:1076-8.
26. Boivin G, Mackay I, Sloots TP, Madhi S, Freymuth F, Wolf D, Shemer-Avni Y, Ludewick H, Gray GC, LeBlanc E. Global genetic diversity of human metapneumovirus fusion gene. Emerg Infect Dis. 2004;10:1154-7.
27. Cohen A, Wolf D, Guttman-Yasski E, Sarid R. Kaposi’s sarcoma associated herpesvirus: clinical, diagnostic and epidemiological aspects. Crit Rev Clin Lab Sci 2005;42:101-53.
28. Arnon TI, Markel G, Saleh N, Katz G, Gazit R, Achdout H, Gonen-Gross T, Hanna J, Nahari E, Honigman A, Plachter B, Mevorach D, Wolf DG*, Mandelboim O*. A novel interaction between HCMV pp65 protein and the NK activating receptor NKp30 leads to global inhibition of NK killing. Nature Immunol. 2005;6:515-2.(the last 2 authors contributed equally to the work)
29. Ofek-shlomai N, Averbuch D, Wolf DG, Engelhard D. Varicella zoster virus encephalitis in a previously healthy five-year-old child with herpes zoster ophthalmicus. Pediatr Infect Dis J. 2005;24:476-7.
30. Wolf DG, Greenberg D, Kalkstein D, Shemer-Avni Y, Givon-Lavi N, Saleh N, Goldberg MD, Dagan R. Virus-Associated Lower Respiratory Tract Infections in Hospitalized Young Children: Comparison of Human Metapneumovirus with Respiratory Syncytial and Influenza A Viruses. Pediatr Infect Dis J. 2006; 25:320-4
31. Azzeh M, Honigman A, Taraboulos A, Rouvinski A, Wolf DG. Structural changes in human cytomegalovirus cytoplasmic assembly sites in the absence of UL97 kinase activity. Virology. 2006; 354:69-79.
32. Megged o, Erlichman M, Kleid D, Wolf DG, Schlesinger Y. Hyponatremia associated with adenovirus infection in twin infants. Eur J Pediatr. 2006; 165:907-8
33. Klement E, Talkington DF, Wasserzug O, Kayouf R, Davidovich N, Bar-Zeev Y, Barkal M, Lanier Thacker W, Wolf D, Lazarovich Z, Shemer Y, Glikman D, Grotto I, Block C, Nir-Paz R. Identification of Risk Factors for Infection in an Outbreak of Mycoplasma pneumoniae Respiratory Tract Disease. Clin Infect Dis 2006;43(10):1239-45.
34. Gazit R, Aker M, Elboim M, Achdout H, Katz G, Wolf DG, Katzav S, Mandelboim O.NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome. Blood. 2007;109:4306-12.
35. Gross M, Wolf DG, Elidan J, Eliashar R. Enterovirus, cytomegalovirus, and Epstein-Barr virus infection screening in idiopathic sudden sensorineural hearing loss. Audiol Neurootol. 2007;12:179-82.
36. Husain S, Kahane S, Friedman MG, Paterson DL, Studer S, McCurry KR, Wolf DG, Zeevi A, Pilewski J, Greenberg D. Simkania negevensis in bronchoalveolar lavage of lung transplant recipients: a possible association with acute rejection. Transplantation. 2007;83:138-43.
37. Abed Y, Wolf D, Dagan R, Boivin G. Development of a serological assay based on a synthetic peptide selected from the VP0 capsid protein for detection of human parechoviruses. J Clin Microbiol. 2007;45:2037-9.
38. Stern-Ginossar N, Elefant N, Zimmermann A, Wolf DG, Saleh N, Biton M, Horwitz E, Prokocimer Z, Prichard M, Hahn G, Goldman-Wohl D, Greenfield C, Yagel S, Hengel H, Altuvia Y, Margalit H, Mandelboim O. Host immune system gene targeting by a viral miRNA. Science. 2007;317:376-81.
39. Elazary AS, Wolf DG, Amir G, Avni B, Rund D, Yehuda DB, Sviri S. Severe Epstein-Barr virus-associated hemophagocytic syndrome in six adult patients. J Clin Virol. 2007;40:156-9.
40. Musallam B, Matoth I, Wolf DG, Engelhard D, Averbuch D.Steroids for deteriorating herpes simplex virus encephalitis. Pediatr Neurol. 2007;37:229-32.
41. Einbinder Y, Wolf DG, Pappo O, Migdal A, Tsvang E, Ackerman Z. The clinical spectrum of cytomegalovirus colitis in adults. Aliment Pharmacol Ther. 2008;27:578-87.
42. Shapira MY , Resnick IB, Chou S, Neumann AU., Lurain NS , Stamminger T, Caplan O, Saleh N, Efferth T, Marschall M, Wolf DG. Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation. Clin Infect Dis. 2008 in Press