Department of Neurosurgery

Hadassah University Hospital

Ein-Karem, Jerusalem

E-mail: ys@md.huji.ac.il

MD Cum-Laude from the Israel Institution of Technology Medical School, 1987

Neurosurgery Residency, Hadassah University Hospital, Jerusalem, 1989-1995

Staff Neurosurgeon, Hadassah University Hospital, Jerusalem since 1995

Lecturer in Neurosurgery, Hebrew University Medical School, since 1995

Research Fellow, The Molecular Genetic Center at the Lerner Research Institution of the Cleveland Clinic Foundation, Cleveland, Ohio, 1997

Research Fellow, Department of Neurosciences at the Lerner Research Institution of the Cleveland Clinic Foundation, Cleveland, Ohio, 1998

Clinical Fellow, Neuro-oncology/stereotactic & Gamma Knife Radiosurgery Department of neurological surgery, Cleveland Clinic Foundation, Cleveland, Ohio, 1998-1999

Visiting Professor at the LINAC - based Radiosurgery unit in New Jersey state University Hospital, (UMDNJ), 2000

Clinical Research

•Safety of perioperative minidose heparin in brain tumor surgery: a prospective, randomized, double-masked Phase II study. Co-investigator

• The Ciba-Geigy Head Injury Trial with CGS-19755 (Selfotel).  Co- investigator

• The International Blood Brain Barrier Disruption Program. Co-investigator

• Safety evaluation of a single IV dose of Dexanabinol (HU 211) in patients suffering from severe head injury – National multicenter Phase II study (Pharmos Corporation).   Principal investigator.

• Efficacy and safety evaluation of a single IV dose of Dexanabinol (HU 211) in patients suffering from sever head injury – International multicenter Phase III study, (Pharmos Corporation).   Principal investigator.

Basic Research exposure

1993-4  Neurooncology laboratory - "The effect of super oxide dismutase on peritumoral brain edema in rat brain tumor model ”with Prof. Tali Siegal.

1995 The Blood Brain Barrier Disruption Program for intraarterial administration of chemotherapy, Portland/Oregon with Dr. Ed Neuwelt.

1997  Research program in the field of molecular Genetics - John K Cowell Ph.D. “ Gene rearrangement on chromosome 10 in GBM”, and “Molecular analyses of radiation –induced meningiomas”. The Molecular Genetic Center, The Lerner Research Institute, Cleveland Clinic Foundation. 

1998  Research in the field of cell biology and development- Bruce D Trapp Ph.D. “Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors” Department of Neurosciences, The Lerner Research Institute, Cleveland Clinic Foundation.

Neurosurgical Certifications

• Israeli Board in Neurosurgery. Specialist’s License No. 20906  -1994

• European Association of Neurological Surgeons (EANS) Certificate  - 1996

Other Certifications:

• ECFMG Certification #: 0-421-215-5  - 1995

• FLEX Certification #: 560414020 - 1993

Memberships – Scientific and Professional Societies.

Active Memberships 

• Israeli Medical Association since 1989

• Israeli Neurosurgical Society since 1995

• Israeli Neurotrauma Society since 1995

• Israeli Surgical Society since 1996

• Israeli Neurosciences Society since 1997

• The American Association of Neurological Surgeon  (AANS) since 1999

• The Congress of Neurological Surgeon  (CNS) since 1999

• The Tumor Section of the AANS since 1999

• The Society for Neuro-Oncology since 2002

Honors and Awards

• Dean’s Honor list of medical Sciences, Technion 1981,1982, 1983, 1984

• Technion - Israel Institution of Technology Medical School  - Cum Laude  - 1987

• Recipient of the best paper award at the 24th neuroscience resident/fellows’ day, The Cleveland Clinic Foundation, 1999, “molecular genetic analyses of radiation-Induced meningiomas”.

Grants for Research

• The Hebrew University and Hadassah University Hospital research grant laboratory study on brain tumor model. 1993 & 1994, 5000$ for each year. Partner – Prof. Tali Siegal.

• The Israeli Chief Scientist of Ministry of Health Stipend for experimental studies on the effect of  superoxide  dismutase on peritumoral  brain  edema  in  rat brain tumor model. 1995 & 1996  (40,000$  each year). Partner – Prof. Tali Siegal.

Bibliography

Papers in peer-reviewed Journal:

1. Ashkenazi E, Constantini S, Shoshan Y, Umansky F, Shalit M.  Surgery for craniophryngioma. Harefuah Vol. 119 (11): p359-361, 1990

2. Shoshan Y, Elami A, Merin G.  Early revascularization after acute myocardial infarction. Harefuah Vol. 120 (3): p113-117, 1991.

3. Shoshan Y, and Umansky F.  Surgical management of posttraumatic malignant brain edema. Harefuah. Vol. 123 (3-4): p122-126, 1992.

4. Elami A, Merin G, Shoshan Y.  Use of Internal mammary artery for urgent myocardial revascularization. Cardiovasc Surg 1(3): p276-279, 1993.

5. Shoshan Y, Pomeranz S, Sofer D, Ashkenazi E, Israel Z, Umansky F. Stereotactic brain biopsy. Harefuah Vol. 128 (8): p470-474, 1995.

6. Shoshan Y, Siegal T.  Control of vasogenic edema in a brain tumor model: Comparison between Dexamethasone and Superoxide dismutase. Neurosurgery 39(6): p1206-1214, 1996. Discussion p1213-1214.

7. Somerville RP, Shoshan Y, Eng C, Barnett HG, Miller D, Cowell JK. Molecular analysis of two putative tumor suppressor genes, PTEN and DMBT, which have been implicated in glioblastoma multiforme disease progression. Oncogene 17 (13): p1755-1757, 1998.

8. Shoshan Y, Akiko N, Chang A, Mork, S, Barnett, HG, Cowell KJ, Trapp BD, Staugaitis MS. Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors. Proc. Natl. Acad. Sci.  96(18):p 10361-10366, 1999.

9. Shoshan Y, Chernova O, Jeun S, Somerville RP, Israel Z, Barnett GH, Cowell JK. Radiation-Induced Meningioma: a distinct molecular genetic pattern? J of neuropathol exp  neurol 59(7): p614-620, 2000.

10. Somerville RP, Chernova O, Liu S, Shoshan Y, Cowell JK. Identification of the promoter, genomic structure and mouse ortholog of LGI 1. Mamm Genome 11(8): p622-627, 2000.

11. Evans JJ, Jeu, SS, Lee JH, Harwalkar JA, Shoshan Y, Cowell JK, Golubic M, Molecular alterations in the neurofibromatosis type 2 gene and its protein rarely occurring in meningothelial meningiomas. J Neurosurg 94: 111-117, 2001.

12. Constantini S, Kanner A, Friedman A, Shoshan Y, Israel Z, Ashkenazi E, Gertel M, Even A, Shevah Y, Shalit M, Umansky F, Rappaport ZH. Safety of perioperative minidose heparin in brain tumor surgery: a prospective, randomized, double-masked study.  J Neurosurg 94:918-921, 2001.

13. Weisberg S, Ashkenazi E, Shoshan Y, Umansky F, Brodie H. Malignant and atypical meningiomas express high levels of FAS and undergo apoptosis in response to FAS ligation. In press. Am J Pathol .

14. Knoller N, Levi L, Shoshan Y, Richental E, Razon N, Rappaport HZ, , Biegon A,  Dexanabinol HU-211 in the treatment of sever closed head injury: a randomized, placebo-controled phase II  clinical trial. In Press Critical Care Medicine.

15. Shoshan Y, Toubi E, Mevorach D. Uptake of C3bi opsonized heterologous apoptotic cells by human monocytes-derived macrophages from patients with systemic lupus erythematosus is impaired due to accelerated apoptosis and loss of “community effect” of monocytes/macrophages. In press J of Immunology.

16. Shoshan Y, Constantini S, Ashkenazi E, Gomori M, Rappaport ZH.  Intramedullary spinal cord renal carcinoma metastasis diagnosed by gadolinium enhanced MRI. Neuro-Orthopedics 11: 117-123, 1991.

18. Constantini S, Ashkenazi E, Shoshan Y, Israel Z, Umansky F.  Thoracic hematomyelia secondary to cumadin anticoagulant therapy: a case report. Eur Neurol 32 (2): p109-111, 1992.

19. Saha D, Shoshan Y, Gomori M.  Intranasal astrocytoma. Ann Otol Rhinol Laryngol 104 (8): p665-7, 1995. (1.124; 9/29; 0)

20. Shoshan Y, Gross E, Cohen P, Pomeranz S. Acute appendicitis of neurosurgical origin.  Eur J Surg 162 (4): p343-345, 1996.

21. Shoshan Y, Maayan S, Gomori JM, Israel Z.  Chronic subdural empyema - a new presentation of neurobrucellosis. Clin Infect Dis 23(2): p400-401, 1996.

22. Lubetzki IK, Ravel VS, Steiner I, Shoshan Y, Hurwitz H. Continuous deterioration in subacute sclerosing panencephalitis during treatment with isoprinosine and intrathecal interferon alpha. Neurol Infect & Epidemiol 2: p163-165, 1997

23. Israel Z., Yacoub, M, Gomori JM, Dotan, S, Soffer, D, Shoshan Y, Spektor S. Rathke's Cleft Cyst Abscess. Pediatric Neurosurgery – 33:159-161, 2000.

24. Shoshan Y, Suh J, Barnett HG. Fractionated Stereotactic Radiosurgery. in LINAC and Gamma Knife radiosurgery - the AANS Neurosurgical Topic Book ed Germano IM. pp. 57-71, 2000

Abstracts:

1. Shoshan  Y, Antebi I, Israel Z, Ashkenazi E, Pomeranz S, Shalit M, Umansky F. Clinical study of 30 patients operated on for suprasellar meningioma.The International Symposium of Skull Base Surgery, Jerusalem, Israel 1993.

2. Shoshan  Y, Antebi I, Israel Z, Ashkenazi E, Pomeranz S, Shalit M, Umansky F. Suprasellar meningiomas: Visual and general outcome following craniotomy.  The Annual Meeting of the American Association of Neurological Surgeon (AANS) 1994. San Diego, California, U.S.A. , J Neurosurg 80: 378, 1994.

3. Shoshan Y, Siegal T. Systemic treatment with recombinant human manganase superoxide dismutase (r-hMnSOD) attenuates vasogenic brain edema in a brain tumor model and in traumatized brain. The Annual Meeting of the Congress of American Neurosurgeons, 1994, Chicago, Illinois, U.S.A.

4. Shoshan Y, Siegal T. Systemic administration of recombinant human manganase superoxide dismutase (r-hMnSOD) is positively affected vasogenic brain edema in a brain tumor model and in traumatized brain. The First International Meeting of the Neurooncology Society, 1994, Mastricht, The Netherlands.

5. Shoshan Y, Siegal T. Systemic treatment with recombinant human manganase superoxide dismutase (r-hMnSOD) is equally effective as Dexamethasone for control of brain edema in a brain tumor model. The Annual Meeting of the American Association of Neurological Surgeon (AANS) 1995. Orlando, Florida, U. S. A. , J Neurosurg 82: 338, 1995.

6. Constantini S, Fridman A, Shoshan Y, Ashkenazi E, Israel Z, Even A, Umansky F, Gartel M, Shevah Y, Rappaport ZH, Shalit M. The safety of perioperative minidose heparin in neurosurgical patients operated for supratentorial brain tumor. A prospective randomized double blind study. The Annual Meeting of the American Association of Neurological Surgeon (AANS) 1994. San Diego, California, U.S.A.

7. Shoshan Y,  Umansky F, Siegal T. Systemic administration of recombinant human manganase superoxide dismutase (r-hMnSOD) attenuates brain edema in a brain tumor model and in traumatized brain. Presented at the Joint Winter Meeting of the Israeli and German Neurosurgical Societies. Eilat, 19-21 of January, 1995.

8. Shoshan Y, Nishiyama A, Barnett HG, Cowell JK, Trapp BD: Are Oligodendrogliomas derived from mature oligodendrocytes or from progenitors cell? Third Biennial Brain Tumor Satellite Symposium of the American Association of Neurological Surgeon (AANS) 1998. Philadelphia, Pennsylvania, USA.

9. Shoshan Y, Chernova O, Harwalker J, Somerville RP, Israel Z, Barnett HG, Cowell JK. Molecular Analyses of Radiation-induced Meningioma. The Annual Meeting of the American Association of Neurological Surgeon (AANS) 1999, New Orleans, Louisiana, USA.

10. Shoshan Y, Rosenthal G, Ashkenazi E, Igus S, Mufid Y, Itshayek E, Umansky F. Clinical experience with routine application of Interactive Image-Guided Neurosurgery System in the treatment of 49 Neurosurgical procedures. Oral presentation at the Third Israeli Symposium on Computer-aids surgery, Medical Robotics, and Medical Imaging ISRACASS 2000, May 2000 Haifa Israel.

11. Knoller N, Levi L, Shoshan Y, Reichental E, Razon N, Rappaport Z.H, Fridman A, Biegon A. Phase II Escalating Dose Clinical Trial of Dexanabinol in Severe Head Trauma. Presented at the Annual Meeting of the Congress of American Neurosurgeons (CNS), section on neurotrauma and critical care. Oct. 11-15, 2000, San-Antonio, Texas.

12. Knoller N, Levi L, Shoshan Y, Razon N, Reichental E, Rappaport Z, Biegon A.
Dexanabinol Improves ICP Management in Severe Head Trauma: Final Results of Phase II Escalating Dose Trial. Accepted for oral presentation at the 11th. International Symposium on Intracranial Pressure and Brain Monitoring (ICP), July 22-27, Cambridge, U.K.

13. Knoller N, Levi L, Shoshan Y, Reichental E, Razon N, Rappaport Z.H, Fridman A, Biegon A. Dexanabinol in Severe Head Trauma: Results of Phase II Clinical Trial. Presented at the 5th. International Neurotrauma Symposium (INTS), Oct. 1-5, 2000, Garmish-Partnerkirchen, Germany.

14. Shoshan Y,Chernova O, Jeun SS, Somerville RP, Israel Z, Barnett HG, Cowell JK. Radiation-induced meningioma: a distinct molecular genetic pattern. Accepted for presentation at the 44th Oholo conference on Blood Brain Barrier drug delivery and brain pathology. 10-14 of September 2000.

15. Shoshan Y, Igus S , Rosenthal G, Mufid Y, Umansky F. Frameless Stereotactic Image-guided surgery for brain tumors in 102 consecutive patients. Accepted for oral presentation at the Annual Israeli Neurosurgical Society meeting. 15 of March 2001.

16. Shoshan Y,Chernova O, Jeun SS, Somerville RP, Israel Z, Barnett HG, Cowell JK. Molecular analysis of post-radiation meningiomas and its implications on radiation therapy for benign tumor of brain. Accepted for oral presentation at the Annual Israeli Neurosurgical Society meeting. 15 of March 2001.

17. Shoshan Y, Weisberg S, Ashkenazi E, Umansky F, Brodie C. Anaplastic and Atypical meningiomas express high levels of FAS and undergo apoptosis in response to FAS ligation. Accepted for presentation at The Annual Meeting of the American Association of Neurological Surgeon (AANS), Toronto, 20-26 of April, 2001.

18. Shoshan Y, Rosenthal G, Igus S, Mufid Y, Itshayek E, Umansky F. Clinical experience with utilization of Frameless Surgical Navigation System in 112 consecutive neurosurgical operations. Accepted for oral presentation at the Fourth Israeli Symposium on Computer-aids surgery, Medical Robotics, and Medical Imaging ISRACASS 2001. 17 of May 2001.

19. Levin N, Gomori JM, Rubinshtein R, Shoshan Y, Siegal T. Delayed radiation induced brain injury (RIBI): Rate of correct prediction by various functional imaging techniques. Accepted for oral presentation at the American Academy of Neurologist. Sep, 2001.

20. Shoshan Y, Weisberg S, Atia M, Israel Z, Ashkenazi E, Umansky F, Brodie C. Expression of specific PKC isoforms in Benign and malignant meningiomas. Accepted for oral presentation at the 12th World Congress of Neurosurgery of the World Federation of Neurosurgical Societies, Sept 2001.

21. John M Gomori, Netta Levin, Rina Rubinstein, Yigal Shoshan and Tali. Siegal. Conventional and functional imaging techniques in patients with delayed radiation-induced brain injury (RIBI). 87th Scientific Assembly and  Annual  Meeting  of  the  Radiologic  Society  of  North  America. Chicago,  IL, November 25 -- 30,  2001.

22. Levin N, Gomori JM, Rubinshtein R, Shoshan Y, Sofer D, Siegal T. The rate of correct prediction of radiation induced brain injury (RIBI) by various functional imaging techniques: a retrospective analysis of 23 patients. Accepted for presentation at the Society of Neuro-oncology meeting. Washington DC, November 15-19, 2001.

More in PubMed