Senior Physician

Department of Bone Marrow Transplantation

And Cancer Immunotheapy

Hebrew University Hospital

Ein-Karem, Jerusalem

Tel office : (972-2) 677 8354

mobile: +(972-50) 7874 663

Fax: +(972-2) 642 2731

E-mail: gashka@hadassah.org.il

Date of birth:  May 15th, 1952

Place of birth: Odessa, USSR (Ukraine)

External position

Head of Dept. Clinical Immunology, Research Institute of Pediatric Hematology (Moscow, Russia),

Professor of Pediatrics

Tel/Fax:  +(7 095) 937 5025 – office

              +(7 095) 936 9247 – clinical unit 

Education, Professional and Academic Degrees

1969 - 1973: High Medical School (Basics, Clinics-1),Donetsk (Ukraine)

1973 - 1975: Pirogov High Medical School (Clinics-2), Odessa (Ukraine)

June, 1975: Medical Doctor Degree (Diploma cum laude); Odessa Pirogov's High Medical School

1975 - 1976: Training internship in medicine, State University Hospital No 3 (Odessa), All-Union Scientific Center of Cardiology (Moscow)Certificate in General Medicine

1976 - 1978: Resident in Pediatrics, Institute of Pediatrics, Academy of Medical Sciences of the USSR, Moscow.  Certificate in Pediatrics

1978 - 1980: Fellowship in Pediatric Allergy/Clinical Immunology, Institute of Pediatrics,  Academy of Medical Sciences of the USSR, Moscow

November, 1981: Candidate of Medical Sciences (Ph.D.) Degree

May, 1988: Doctor of Medical Sciences (D.Sc.) Degree.

1992-1993: Training in neonatology, Instituto  Materno  Infantile of Palermo  University (Italy)

1995: Observer in Children’s Hospital and Center for Blood Research, Harvard Medical School (USA)

1997: Training in pediatric immunology/bone marrow transplantation unit in Spedali Civili University of Brescia (Italy)

1998: Superior category qualification in pediatrics (Russia)

1999: Certificate of Specialist in Allergy and Clinical Immunology

2000: observer in pediatrics, in Hadassah University Hospital

2000: Israeli Certificate of Expert in Pediatrics

Appointments

1980 - 1988: physician, senior physician and senior investigator, physician-consultant in allergy/immunology and infection diseases and leading investigator, Institute of Pediatrics, Academy of Medical Sciences of the USSR, Moscow.

1993 till present: Head of Dept. Clinical Immunology,  Research Institute of  Pediatric Hematology, Moscow

From 1995: Professor of Pediatrics, Russian State Medical University, Moscow

1992 - 1993: Invited researcher of Instituto  Materno  Infantile of Palermo University and  Hospital “Buccheri La Ferla" for the  common  research in pediatric allergy (Italy).

1994 to 1996: President of "Pediatric Allergy/Immunology Foundation"

1994 till present: Member and vice-president (1995 to 2000) of specialized council D.084.64.01 for doctoral thesis defense.

1996: Visiting researcher, INSERM U430 (Paris, France)

2000 till present: Instructor in medicine, course of hematology and bone marrow transplantation and course of introduction in medicine, School of Medicine, Hebrew University, Jerusalem

Current Scientific Activity

Team leader of 4 senior researchers, 3 researchers, and  5 PhD students in Research Institute of Pediatric Hematology (Moscow, Russia)

Postgraduate Students, Postdoctoral and Fellows

The 13 PhD students and 2 postdoctoral investigators have been graduated or continue their investigation under my direct supervision in pediatrics, hematology / transfusiology and allergy / immunology:

Memberships 

1. WHO/IUIS Scientific Group for Primary Immunodeficiency Disorders (from 1994)

 2. British Society for Immunology (from 1997)

 3. Russian Pediatric Society  (member of the Council  in 1994-1996)

 4. European Society for Immuno deficiencies (ESID) (from 1992)

Scientific Interests and Future Research Program

1. Clinical and experimental hematopoietic stem cell transplantation for nonmalignant disease (genetic, autoimmune, etc.).

2. founder effect in Nijmegen breakage syndrome (in collaboration with Institute of Human Genetics of Charite Humboldt University, Berlin, Germany).

3. genetic basis of apoptosis, defects in autoimmune proliferative syndrome, pharmacologic regulation (in collaboration with the laboratory INSERM 429, Paris, France).

4. non-infectious symptoms in primary immunodeficiencies PID. This project is due to be performed in Department of Clinical Immunology, Institute of Pediatric Hematology, Moscow, Russia.

List of Scientific Works(original papers, reviews, proceedings, abstracts and books/chapters) consists of more then 160 items; important from last years:

1. Resnick IB, Kondratenko I, Togoev O, Vasserman N, Shagina I, Evgrafov O, Tverskaya S, Cerosaletti KM, Gatti RA, Concannon P. Nijmegen breakage syndrome: clinical characteristics and mutation analysis in eight unrelated Russian families.J Pediatr 2002 Mar;140(3):355-61.

2. Igor B. Resnick, Oleg Togoev, Alexey A. Maschan, Alexander Karachunsky, Timakov, Svetlana Tverskaya, Oleg Evgrafov, Alexander G. Roumiantsev. Association of the 657del5 Nijmegen Breakage Syndrome Mutation with Childhood Lymphoid Tissue Malignancies. American J Medical Genetics 2002 (accepted)

3. Or R, Shapira MY, Resnick I, Amar A, Ackerstein A, Samuel S, Aker M, Naparstek E, Nagler A, Slavin S.Nonmyeloablative allogeneic stem cell transplantation for the treatment of chronic myeloid leukemia in first chronic phase. Blood 2002 Sep 19

4. Ranganathan V, Heine WF, Ciccone DN, Rudolph KL, Wu X, Chang S, Hai H, Ahearn IM, Livingston DM, Resnick I, Rosen F, Seemanova E, Jarolim P, DePinho RA, Weaver DT. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Curr Biol 2001 Jun 26;11(12):962-6.

5. Lacroix-Desmazes S, Resnick I, Stahl D, Mouthon L, Espanol T, Levy J, Kaveri SV, Notarangelo L, Eibl M, Fischer A, Ochs H, Kazatchkine MD. Defective self-reactive antibody repertoire of serum IgM in patients with hyper-IgM syndrome. J Immunol 1999 May 1;162(9):5601-8.

6. Vihinen M, Kwan SP, Lester T, Ochs HD, Resnick I, Valiaho J, Conley ME, Smith CI. Mutations of the human BTK gene coding for bruton tyrosine kinase in X-linked agammaglobulinemia. Hum Mutat 1999;13(4):280-5.

7. Levy J, Espanol-Boren T, Thomas C, Fischer A, Tovo P, Bordigoni P, Resnick I, Fasth A, Baer M, Gomez L, Sanders EA, Tabone MD, Plantaz D, Etzioni A, Monafo V, Abinun M, Hammarstrom L, Abrabamsen T, Jones A, Finn A, Klemola T, DeVries E, Sanal O, Peitsch MC, Notarangelo LD. Clinical spectrum of X-linked hyper-IgM syndrome. J Pediatr 1997 Jul;131(1 Pt 1):47-54.

8. Macchi P, Villa A, Strina D, ... Resnick I, et. al. Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry. Am J Hum Genet 1995 Apr;56(4):898-906

9. Rosen F.S., M.Eibl, C.Roifman, A.Fischer, J.Volanakis, F.Aiuti, L.Notarangelo, T.Kishimoto, I.B.Resnick, L.Hammarstrom, R.Seger, H.Chapel, M.D.Cooper, R.S.Geha, R.A.Good, T.A. Waldmann, R.J.P. Wedgwood. Primary Immunodeficiency Diseases. Report of an WHO/IUIS Scientific Committee. Clinical and Experimental Immunology 1999, 118 (Suppl. 1): 1-28.

10. I.Resnick, O.Danhaive V.Rosella U.Dimita. L'asma in pediatria. Manuale teorico prattico. Plada S.p.A.,Milano, 1994. [Italian.]

11. Consensus report of expert group. Bronchial asthma in children: A treatment strategy and prophylaxis (Journal version prepared by Prof. N.A. Geppe and Prof. I.B.Resnick). Russian Journal of Medicine [in Russian]1998;6, 2:3-48.

12. Scherbina A. Yu. , Bretcher A., Rozen F. S., Rumyantsev A. G., Remold-O’Donnell E., Resnick I. B. Low concentration of moezin, a cytoskeletal protein, in platelets of patients with Wiskott-Aldrich syndrome. Hematologia – Transfusiologia [Russian] 1999, vol.44, 4: 17-21

13. IB Resnick , I.Kondratenko, I.Molotkovskaya, E.Konopleva, Y.Reznicov, L.Baydun, V.Poverenny, F.Rieux-Laucat, F. Le Deist. Autoimmune Lymphoproliferative Syndrome (ALPS) in Children. IX Meeting of the European Society for Immunodeficiencies. Proceedings. /A.Etzioni - ed. Monduzzi Editore S.p.A. –2000: p.197-205.