Attending physician

Department of Oncology

Hadassah Medical Center

Senior Lecturer

Hebrew University-Hadassah Medical school

Jerusalem Israel

Education

1984  BSc. in Biology -Hebrew university Jerusalem with  distinction

1991 Ph.D in Biochemistry- Hadassah Medical School, Jerusalem. Regulation of the PEPCK gene in adipose tissue -  Supervision: Prof. L. Reshef

1996 M.D. Hebrew University-Hadassah Medical School

1995-6 Internship at Hadassah Ein Kerem, Jerusalem. 

1996-2001 Residency in oncology at Hadassah, Ein Kerem, Jerusalem.

2002-2005 Research fellowship- tumor immunology  In the lab of  Prof. J.D. Rosenblatt University of Miami

2005-present – attending physician  Oncology department Hadassah medical center

2006 - appointed senior lecturer Hadassah Hebrew University medical center

Publications (from 2000) in peer reviewed Journals

1. Nechushtan H., Leitges M. Cohen C, Kay G and Razin E.:  Pkc beta defficient mast cells. , Blood. 95:1752-1757. 2000

2. Nechushtan H..,  and Razin E.,. Studies of different aspects of the role of protein kinase c in mast cells. Int Arch Allergy Immunol.;124(1-3):130-2. 2001

3. Levy c.,Nechushtan H., Razin E:  A new role for the STAT3 inhibitor, PIAS3: A repressor of microphthalmia transcription factor J Biol Chem;277(3):1962-6. . 2002

4. Nechushtan H., and Razin E.,: The function of MITF and associated proteins in mast cells. Mol Immunol. 38:1177, 2002

5. Nechushtan H.  and Peretz  T.,. Tamoxifen and breast cancer. Harefuah. 141:718-20 2002

6. Rosenblatt JD, Shin SU, Nechustan H, Yi KH,, Tolba K,. Potential role of chemokines in immune therapy of cancer Isr Med Assoc J  11: 1054-9 2002

7. Cohen-Saidon C, Nechushtan H, Kahlon S,Livni N, Nissim A,, Razin E A novel strategy using single-chain antibody to show the importance of Bcl-2 in mast cell survival. Blood. 2003  102 :2506-12 (first two authors contributed equally to this work)

8. Lee, Y.-N ,Nechushtan, H,  Figov, N., Razin, E   A novel function of lysyl-tRNA synthetase and diadenosine tetraphosphate (Ap4A) as a signaling regulator of the activity of microphthalmia transcription factor in FcRI-activated mast cells. Immunity 2004  20:145-151 (first two authors contributed equally to this work)

9. O. Merimsky, E. Gez, R. Weitzen, H. Nehushtan, R. Rubinov, H. Hayat, T. Peretz M. Ben-Shahar, H. Biran, R. Katsenelson, V. Mermershtein, D. Loven, N. Karminsky, A. Neumann, D. Matcejevsky and M. Inbar. Targeting pulmonary metastases of renal cell carcinoma by inhalation of interleukin-2. Annals of Oncology  15: 610–612 2004

10. Lee YN, Tuckerman J, Nechushtan H, Schutz G, Razin E, Angel P,c-Fos as a regulator of degranulation and cytokine production in FcepsilonRI-activated mast cells J Immunol  2004  15:173:2571-7 2004.

11. Lu X, Nechushtan H, Ding F, Rosado MF, Singal R, Alizadeh AA, Lossos IS.. 2005 Distinct IL-4 induced gene _expression, proliferation and intracellular signaling in germinal center B-cell like and activated B-cell like diffuse large cell lymphomas.: Blood.;105:2924-32) 2005

12. Cho HM, Rosenblatt JD, Kang YS, Iruela-Arispe ML, Morrison SL, Penichet ML, Kwon YG, Kim TW, Webster KA, Nechustan H, Shin SU. Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein.Mol Cancer Ther. 2005 (6):956-67

13.Shah S, Divekar AA, Hilchey SP, Cho HM, Newman CL, Shin SU, Nechustan H, Challita-Eid PM, Segal BM, Yi KH, Rosenblatt JD Increased rejection of primary tumors in mice lacking B cells: inhibition of anti-tumor CTL and TH1 cytokine responses by B cells Int. J Cancer 2005 :117574-86.

14. Nechushtan  H  and   Razin E  Mast cells: must they always be different?  Blood 2006 107: 1-2.

15. Levy C, Lee YN, Nechushtan H, Schueler-Furman O, Sonnenblick A, Hacohen S, Razin E.Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3. Blood. 2006  1;107(7):2839-45

16. Benhamron S, Nechushtan H, Verbovetski I, Krispin A, Abboud-Jarrous G, Zcharia E, Edovitsky E, Nahari E, Peretz T, Vlodavsky I, Mevorach D.Translocation of active heparanase to cell surface regulates degradation of extracellular matrix heparan sulfate upon transmigration of mature monocyte-derived dendritic cells.J Immunol;176 (11):641 2006

17. Tshori, S., Gilon, D., Beeri, R., Nechushtan, H.,Kaluzhny, D., Pikarsky, E.,   and Razin, E. Transcription factor MITF regulates cardiac growth and hypertrophy. J Clin Invest, 116: 2673-2681, 2006

18. Kadouri, L., Hubert, A., Rotenberg, Y., Hamburger, T., Sagi, M., Nechushtan, C., Abeliovich, D., and Peretz, T. Cancer risks in carriers of the BRCA1/2 Ashkenazi founder mutations. J Med Genet, 2007.

19. Tshori,    S., Sonnenblick A ,Yannay-Cohen N, Kay G  Nechushtan, H  Razin, The Microphthalmia Transcription Factor Isoforms in Mast Cells.   E Mol Cell Biol, 27: 3911-3919, 2007.

20. Yi K H, Nechushtan H,  Bowers  WJ  Walker GW, Zhang Y, Pham  DG,  Podack ER, Federoff H,  Tolba KA, and JD. Rosenblatt1, Adoptively transferred tumor-specific T cells stimulated ex vivo using HSV amplicons encoding 4-1BBL persist in the host and demonstrate anti-tumor activity in vivo  Accepted for publication in Cancer Research July 2007

21. Nechushtan, H Pham D,  Zhang, Y Morgensztern,D   Yi K.H. , Shin SH,  Federoff H, Bowers W.J , Tolba  KA and .Rosenblatt JD  Augmentation of anti-tumor responses of adoptively  transferred CD8+T    cells in the lymphopenic setting by HSV amplicons. accepted for publication 9.07 in Cancer Immunology and Immunotherapy.