Acting Head

Hadassah University Hospital

Mount Scopus, Jerusalem

Tel: 02-5844582 Fax: 02-5810918

E-mail - meiner@hadassah.org.il

Born in 18.11.1957,

Tel Aviv, Israel. 

Married with two children.

Academic Education

1979-1986  Hebrew University Hadassah Medical School, Jerusalem.

1982  Graduated B.Sc in Medical Science with honors.

1986  Graduated M.D. degree. Hebrew University - Hadassah Medical School

1986 Rotating Internship Hadassah University Hospital, Jerusalem. Israeli Licence to practice medicine No. 019825 

1987-1992  Residency in Neurology in the Department of Neurology, Hadassah University hospital, Jerusalem. Chairman: Prof. Oded Abramsky.

 1992-1994  Attending physician, Department of Neurology, Hadassah University Hospital, Jerusalem. Chairman: Prof. Oded Abramsky.

1994-1996  Postdoctoral fellowship in: Nobel Laurite Stanley B. Prusiner’s Laboratory,  Department of Neurology, University  of California, San Francisco.

1997-2000  Neurological Consultant , Department of Geriatric, Hadassah University hospital, Jerusalem.  Chairman: Prof. Jochanan Stessman

Now - In charge of the Neurogeriatric and Memory clinic, Hadassah University Hospital, Mount Scopus, Jerusalem.

Residency in Physical Medicine and  Rehabilitation, Department of Physical Medicine and  Rehabilitation Hadassah University Hospital, Mount Scopus, Jerusalem. Chairman: Prof. Mara Shochina.

2003 - Now  Senior physician,  Department of Physical Medicine and Rehabilitation Hadassah University Hospital, Mount Scopus, Jerusalem. Chairman: Prof. Mara Shochina.

Military service- IDF Reserve

1976-1979    Israel Defense Forces. Officer in Artillery Unit. 

1980- Now    Israel Defense Forces. Air force Neurologist.  Present rank: Major

Appointments at the Hebrew University and Hadassah University Hospital:

1990 - Part I - Boards in Neurology

1992 - Part II- Boards in Neurolog, Certified Israeli Neurological licence  No. 12501

1990-1992  Instructor in Neurology, Hebrew University, Faculty of Medicine, Jerusalem.

1992-1996  Lecturer in Neurology, Hebrew University, Faculty of Medicine, Jerusalem

2003 - Boards in Physical Medicine and Rehabilitation, Certified.Israeli Physical Medicine & Rehabilitation licence  No. 20473

2007 - Senior Lecturer in Physical Medicine and Rehabilitation, Hebrew University, Faculty of Medicine, Jerusalem  

Other Activities

Since 1992- Consultant in the National Insurance Institute  

1999-2002- Treasury of the Israeli Neurological Association

Member of the Alzheimer’s Association committee for biological tests for diagnosis of Alzheimer’s disease

Member of the Ministry of Health committee for Apotropos appointment

Member of the scientific committee of the Israel Alzheimer's Association

Member of the following Societies: 

§         1987- Israel Neurological Society

§         1992- American Academy of Neurology

§         2003- Israel Rehabilitation and Physical Medicine Society

§         2003- International Society of Physical and Rehabilitation Medicine

Prizes

1986 - The Lipa Halperin Prize of the Hebrew University, Hadassah Medical School for M.D. Thesis “The Locus Ceruleus in Parkinson’s Disease”

1989 - Outstanding Resident award of Hadassah University  Hospital

1995 - Bernardo Akermann fellowship of the Israel Medical Association - Creutzfeldt-Jakob disease in Jews of Libyan Origin” – 2000 $

2004 - An outstanding lecture of the Faculty of Medicine .

2006 -  An outstanding lecture of the Faculty of Medicine .

Research Grants

1992 - Research grant from the Bilateral fund of Hadassah Hospital and  Hebrew University Medical School- “Prion protein in peripheral tissues of Libyan Jews with Creutzfeldt-Jakob disease” – 10,000 $

1996 - Alzheimer’s association/Helen and Philip Brody Pilot Research Grant  ”Regulation of PrP expression by the tetracycline-regulated system - implication for neurodegenerative diseases” – 30,000 $

1997 - United-States-Israel Binational Science Foundation Grant- ”Pathophysiological Mechanisms of Creutzfeldt-Jakob Disease in Libyan Jews”- 40,500 $

Henry N. Neufeld memorial award for research grant  ”Pathophysiological Mechanisms of Creutzfeldt-Jakob Disease in Libyan Jews” – 10,000 $

1997 - Research grant from the Joint research fund of the Hebrew University Medical School and Hadassah Hospital in gene therapy- “ Regulation of the expression of the normal prion protein as a mean of gene therapy for inherited prion diseases”– 35,000$

1997 - Israeli chief scientist grant- Investigation of infectivity and treatment of familial Creutzfeldt-Jakob disease in Libyan Jews using transgenic mice carrying the E200K mutation of the prion protein gene –60,000 IS

2006 - Israeli chief scientist grant- fMRI of stroke patients treated by CIMT-  20,000 IS.

2007 - Israeli chief scientist grant- The Effectiveness of Locomotor Therapy Using the LOKOMAT System in Patients with Cerebrovascular Accidents (CVA), Spinal Cord Injuries (SCI) and Traumatic Brain Injuries (TBI). Prof. M Shochina & Dr. I Schwartz. 200,000 IS.

Teaching at the Hebrew University:

1. Doctoral Thesis: Apoptosis in Prion diseases. M.D. thesis by the student Subchi Abady– 2002 (In colaboration with Prof. Tamir Ben-Hur).

2. Teaching:

1. M.D. students in 5th year Neurology- Alzheimer’s Disease and other Dementias

2. M.D. students in 5th year Rehabilitation and Physical Medicine-Neurological  Rehabilitation-

3. M.A. and B.A. students in medical science- The biology of Neurodegenertaive   

    Diseases-

List of Publications

1. Hsiao K PI, Meiner Z PI, Kahana E PI, Cass CT, Kahana IT, Avrahami DT, Scarlato GT, Abramsky O PI,  Prusiner SB PI, Gabizon R PI. Prion protein mutation in Libyan Jews with Creutzfeldt-Jakob disease. N Eng J Med, 324:1091-1097,1991.

2. Reches A PI, Meiner Z PI. The Locus Coeruleus and dopaminergic function in rat brain: Implication to parkinsonism. Brain Res Bull. 28:663-666, 1992.

3. Meiner Z PI, Halimi MT, Polakiewicz RDT, Prusiner SB PI, Gabizon R PI.  Presence of the prion protein in peripheral tissues  of Libyan Jews with Creutzfeldt-Jakob disease. Neurology, 42:1355-1360, 1992.

4. Meiner Z PI, Ben-Hur T PI, River Y PI, Reches A PI.  Aseptic meningitis as a complication of  intravenous immunoglobulin therapy for myasthenia  gravis. J of Neurology, Neurosurgry and  Psychiatry, 56:830-831, 1993.

5. Gabizon R PI, Rosenmann H PI, Meiner Z PI, Kahana IT, Kahana E PI, Shugart YC, Ott JC, Prusiner SB PI. Mutation and polymorphism of the prion protein gene in Libyan Jews with  Creutzfeldt-Jakob disease. Am J Human Genetics, 53:828-835, 1993

6. Gabizon R PI, Meiner Z PI, Halimi MT, Ben-Sasson SC. Heparin-like molecules bind  differentially to prion-proteins and change their intracellular metabolic fate. J of  Cellular Physiol, 157:319- 325, 1993

7.Meiner V PI, Meiner Z PI, Reshef AT, Bjorkhem IC Leitesdorf E PI. Cerbrotendinous    xanthomatosis: molecular diagnosis enables pre-symptomatic detection of a treatable disease.  Neurology, 44:288-290, 1994

8. Gabizon RPI, Halimi MT, Meiner ZPI. Genetics and biochemistry of Creutzfeldt-Jakob disease in  Libyan Jews. Biomedicine and Pharmacotherapy, 48:385-390,1994 9.Averbuch-Heller LPI, Meiner Z. PI Reversible periodic alternating gaze deviation in hepatic encephalopathy. Neurology, 45:191-192,1995

10. Spudich SPI, Mastrianni J API, Wrensch MT, Gabizon RPI, Meiner ZPI, Kahana IS, Rosenmann HPI, Kahana EPI, Prusiner SBPI.  Complete penetrance of  Creutzfeldt-Jakob disease in Libyan Jews carrying the E200K mutation in the prion protein gene. Mol. Med, 1:607-613,1995

11.Gabizon RPI, Telling GPI, Meiner ZPI, Halimi MT, Kahana IS, Prusiner SBPI. Insoluble wild-type and protease-resistant mutant prion protein in brain of patients with inherited prion disease. Nature Medicine,  2:59-64,1996

12. Karussis DMPI, Meiner ZPI, Lehmann DC, Gomori JMC, Schwartz AC, Linde AC, Abramsky OPI. Treatment of secondary progressive multiple sclerosis with the immunomodulator linomide: A double-blind, placebo-controlled pilot study with monthly MRI evaluation. Neurology, 47:341-346,1996

13.Meiner ZPI, Gabizon RPI, Prusiner SBPI. Inherited Creutzfeldt-Jakob disease in Libyan Jews caused by mutation at codon 200 in the prion protein gene. Medicine (Baltimore) 76: 227-237,1997

14. Meiner ZPI, Arber NPI, Liberman ES, Leibovitz EC, Seltzer DC, Berliner SPI. Increased leukocyte adhesiveness/aggregation in patients with recurrent TIA. Acta Neurol Scand 96:123-126,1997

15. Rosenmann HPI, Meiner ZPI, Kahana EC, Halimi MT, Lenetsky EC, Abramsky OC, Gabizon RPI. Detection of 14-3-3 protein in the CSF of genetic Creutzfeldt-Jakob dise. Neurology 49: 593-595,1997

16.Tremblay PPI, Meiner ZPI, Galou MC, Heinrich CT, Petromilli CT, Lisse TT, Cayetano JT, Torchia MT, Mobley WC, Bujard HC, DeArmond SJC, Prusiner SBPI. Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proc Natl Acad Sci USA 95:12580-12585,1998

17. Lossos API, Meiner ZPI, Barash VPI, Soffer DC, Schlesinger IC, Abramsky OC,  Argov ZC, Shpitzzen ST, Meiner VPI. Adult  polyglucosan body disease in Ashkenazi Jews carrying the Tyr329Ser mutation  in the glycogen branching enzyme gene. Ann Neurol, 44:867-872, 1998

18.Rosenmann HPI, Talmor GS Halimi MT, Yanai AC, Gabizon RPI, Meiner ZPI.  Prion protein with an E200K mutation displays properties similar to those of the cellular isoform PrP(C). J  Neurochem.  76:1654-62, 2001.

19. RosenmannPI, Meiner ZPI, Kahana EC, Aladjem ZC, Friedman GC, Ben-Yehuda AC, Grenader TC, Wertman EC, Abramsky OPI. A polymorphism in the complement component C1r is not associated with sporadic Alzheimer's disease. Neurosci Lett. 16;336(2):101-4, 2003.

20. Rosenmann HPI, Meiner ZPI, Kahana EC, Aladjem ZC, Friedman GC, Ben-Yehuda AC,  Grenader TC, Wertman EC, Abramsky OPI. An association study of the codon 72 polymorphism  in the pro-apoptotic gene p53 and Alzheimer's disease. Neurosci Lett.  3;340(1):29-32, 2003.

21.Lossos API, Reches API, Gal AT, Newman JPC, Soffer DC, Gomori JMC, Boher MC, Ekstein  DC, Biran IC, Meiner ZC, Abramsky OPI, Rosenmann H. Frontotemporal dementia and parkinsonism with  the P301S tau gene mutation in a Jewish family. J Neurol. 250(6):733-40, 2003.

21.  Rosenmann HPI, Meiner ZPI, Kahana EC, Aladjem ZC, Friedman GC, Ben-Yehuda AC, Grenader TC, Wertman EC, Abramsky OPI. The Fas Promoter Polymorphism at Position -670 Is  Not  Associated with Late-Onset Sporadic Alzheimer's Disease. Dement Geriatr Cogn Disord. 17(3):143-146, 2004.

22.  Rosenmann HPI, Meiner ZPI, Kahana EC, Aladjem ZC, Friedman GC, Ben-Yehuda AC, Grenader TC,Wertman EC, Abramsky OPI.  Lack of association of interleukin-1beta  polymorphism with  Alzheimer's disease in the Jewish population. Neurosci Lett. 10;363(2):131-3, 2004.

23. Rosenmann HPI, Meiner ZPI, Kahana EC, Aladjem ZC, Friedman GC, Ben-Yehuda AC, Grenader TC,Wertman EC, Abramsky OPI. An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer's disease. Am J Med Genet. 1;128B(1):123-5, 2004.

24.  Geylis VS, Kourilov VS , Meiner ZPI, Nennesmo I C, Bogdanovic N C Steinitz MPI. Human monoclonal antibody against amyloiD-Beta from Healthy adult. Neurobiology of Aging Neurobiol Aging. 26(5):597-606, 2005.

25. Meiner ZPI . Newman JP PI, Rosenman, HC, Soffer, DC, Steiner, IPI. Progressive visual-spatial dementia: An unusual disorder with ubiquitinated neuronal inclusions. Neuology. 65:478-480, 2005.

26. Rosenmann H PI, Meiner Z PI, Geylis Vt, Abramsky O PI, Steinitz MPI. Naturally occurring antibodies against unphosphorylated and phosphorylated tau protein  in  Alzheimer’s disease and healthy subjects. Neurosci Lett. 20;410:90-3,2006.

27. Schwartz IPI, Tsenter JPI , Shochina MPI, Shiri St, Kedary Mt, Katz-Leurer M PI, Meiner  ZPI . Rehabilitation Outcome of Terror Victims with multiple trauma. Arch. of Physical Medicine and Rehabilitation 4.2007.