Professor Shlomo Maayan
Director of Hadassah AIDS Center (HAC)
Specialist in Internal Medicine
Specialist in Infectious Diseases
Address
Aids center
Department of Clinical Microbiology and Infectious Diseases
Hadassah
Hebrew-University Hospital
Kiryat Hadassah P.O.B. 12000
Jerusalem 91120
ISRAEL
e.mail: shlomo_m@hadassah.org.il
Date of Birth: April 6, 1946
EDUCATION
1967-68 Bologna University Medical School, Bologna, Italy.
1969-73
· Sackler Medical School, Tel Aviv, Israel.
· Rotating internship, Central Hospital for the Negev, Beer Sheba, Israel.
· MD degree - Sackler Medical School, Tel Aviv.
· Field Doctor, Bedouin Tribes, South Sinai.
· Internal Medicine, Coney Island Hospital, Brooklyn, N.Y. (Internship).
1977-79 Internal Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA (Residency).
1979-81
· Infectious Diseases, Albert Einstein College of Medicine, Bronx, N.Y. (Fellowship).
· Harvard School of Public Health, Boston (Post Doc.).
1995 McGill AIDS Center, Montreal (Post Doc.).
MEDICAL LICENSES:
New York
Massachusetts
Israel
POSITIONS:
1981-84 Director, Infectious Diseases Unit - Metropolitan Hospital, NY City.
Assistant Professor - New York Medical College 1981 - 1984
1984-99 Senior Consulting Physician - Department of Clinical Microbiology and Infectious Diseases, Hadassah Hospital, Jerusalem.
1990-98 Director, AIDS Clinic, Hadassah University Hospital.
1993-95 Consultant - The West Bank Health Authority.
Chairman - Subcommittee on AIDS among drug abusers - The Israeli KNESSET.
1997-2008 Director, Hadassah AIDS Center (HAC).
ACADEMIC TITLES:
1981-1984 Assistant professor, NY Medical College, NY.
2000-2007 Associate Clinical Professor of Virology at the Hebrew University, Jerusalem.
LIST OF PUBLICATIONS
Chapters in Books
1. S. Maayan. Epidemiology of HIV-1 in the developing world. In: AIDS, a Global Phenomenon. Editor: A. Morag, Academon publishing 1998; section 1; 85-101.
2. Y. Lasri, S. Maayan, E. Rubinstein. AIDS in adults – in: AIDS, a Global Phenomenon. Editor: A. Morag, Academon publishing 1998; section 2: 115-137.
3. S. Maayan. Human immundeficiency virus, in: Textbook of Perinatal Medicine Asim Kurjak, Editor, Parthenon publishing, First edition 1998; section 17: 1604- 1608.
4. Maayan S and Ramlawi A , Joint Efforts of Hadassah and the Palestinian Authority in Curbing HIV/AIDS, in: Barnea T and Husseini R, Separate and Cooperate, Cooperate and Separate, Westport: Praeger Publishers, 2002.
5. Pops-Olshtein K, and Maayan S. HIV infection in pregnancy and delivery. in:Textbook of Perinatal Medicine. Asim Kurjak, Editor, Parthenon publishing, Second edition 2005.
PAPERS IN PEER REVIEWED JOURNALS:
Original Research Papers
1. H. Masur, M.A. Michelis, G.P. Wormser, S. Maayan et al. (1982).Opportunistic infections in previously healthy women. Annals of Internal Medicine. 97:533-38.
2. M. Wittner, S. Maayan. (1983). Diagnosis of Giardiasis by two methods.Archives Path Lab Med. 107:524-28 .
3. F.P. Duncanson, S. Maayan, D. Hewlett. (1983). TB-A harbinger for AIDS. Clinical Research. 31:619A.
4. H. Brody, S. Maayan. (1983). Cytomegalovirus seropositivity in two populations of drug abusers. NIH AIDS memorandum.
5. E. Rieber, A. Mittelman, G.P. Wormser, S. Maayan. (1984). Vincristineand Kaposi's sarcoma in the acquired immunodeficiency syndrome. Annals of Internal Medicine. 101:876 .
6. D. Hewlett, S. Maayan, G.P. Wormser.( 1985). Reversal of T-cell helper& suppressor ratios in intravenous drug abusers with non opportunistic infections. Journal of Infectious Diseases. 151:748.
7. BS. Koppel, G.P. Wormser, A. Tuchman, S. Maayan. (1985). Central nervous system involement in patients with acquired immunodeficiencysyndrom. Acta Neurologica Scandinavica. 71(5):337-53.
8. S. Maayan, G.P. Wormser, S.N. Miller, et al. (1985). AIDS in an economically disadvantaged population. Archives of Internal Medicine. 145(9): 1607-12.
9. S. Maayan, G.P. Wormser, R. Backenroth, E. Rieber. (1985). Antibody tolymphadenopathy associated virus in various groups of illicit drug abuseres in N.Y.city. Journal of Infectious Diseases. 152: 843.
10. C.E. Cherubin, S.M. Smith, S. Maayan. (1985). The impact of third generation cephalosporins on clinical outcome of gram-negative meningitis in a municipal hospital. New York State Journal of Medicine. 85:243-4.
11. A. Karpas, S. Maayan, R. Raz. (1986 ). Lack of antibodies to adult T-cell leukemia virus (ATLV-HTLV1) and to AIDS virus among Israeli Falashas. Nature. 319: 794.
12. F.P. Duncanson, D. Hewlett, S. Maayan, et al.( 1986). M. Tuberculosis infection in the acquired immunodeficiency syndrom. A review of 14 cases. Tubercle. 67: 295-302.
13. JM Wu, JW Chiao, S. Maayan. (1986 ). Diagnostic value of the determination of an interferon iduced enzyme activity decreased 2w, 5w oligoadenylate dependent binding protein activity in AIDS patients' lymphocytes. AIDS Research and Human Retroviruses. 2 (2): 127-31.
14. Y. Siegman-Igra, S. Maayan, S. Pitlik, C. Costin, T. Schwartz, D. Michaeli. (1988). The epidemiology and clinical manifestations of AIDS in Israel. Israel Journal of Medical Sciences. 24: 131-6.
15. S. Maayan, D. Engelhard, S. Boger, A. Ganer, A. Morag, M. Shapiro, T. Sacks.(1989). Epidemiological observations in the Hadassah Medical Center AIDS clinic. Israel Journal of Medical Sciences. 25: 309-13.
16. D. Engelhard, A. Morag, R. Or, E. Naparstek, M. Aker, S. Maayan, S. Slavin. (1988). Prevention of Herpes simplex virus (HSV) infection in recipients of HLA - matched T lymphocyte depleted bone marrow allografts. Israel Journal of Medical Sciences. 45: 145-150.
17. Z. Ackerman, A. Zeltzer, S. Maayan. (1989). Acquired Immune Deficiency Syndrome and Oropharyngeal Candidiasis. Israel Journal of Dental Sciences. 2: 162-7.
18. M. Schlesinger, O. Afik, O. Loves, S. Maayan, R. Rabinowitz. (1990). Changes in the level of soluble CD2 molecule in the serum of HIV infected individuals. Cancer Detection & Prevention. 14: 347-51 .
19. S. Maayan, G. Moreli, D. Engelhard, Z. Ackerman, M. Shapiro, H. Bercovier, T. Sacks. (1991). Legionellosis at Hadassah University Hospital. Israel Journal of Medical Sciences. 27: 145-9, 1991 .
20. A. Moses, S. Maayan, Y. Shvil, I. Doudin, I. Polacheck. (1991). Hansenulla Anomala infections: From colonization to tissue invasion. Pediatric Infectious Diseases. 400-2.
21. A. Okayamma, B. Korber, Y. Chen, J. Allan, T.H. Lee, N. Muller, S. Maayan, M. Essex. (1991). Unusual pattern of antibodies to HTLV1 in family members of Adult T-cell leukemia patients. Blood. 78(12) 3323-29.
22. S. Maayan, M. Dan, R. Marling, Y.M. Chen. (1992). HTLV among Israeli IV drug abusers. Int J . of Epidemiology. 21: 995-7 .
23. S. Maayan, Y. Yust, N. Vardinon, Yazkan R. (1993). Lack of exposure to HTLV among Ethiopian immigrants of operation Solomon (1991) arriving to the Jerusalem area. Israel Journal of Medical Sciences. 29: 393-5.
24. M. Alkan, S. Maayan, I. Belmaker, I. Arbeli, N. Manny. (1993). Serological markers for Hepatitis B, C and Treponemal infection among HIV carriers from Ethiopia. Israel Journal of Medical Sciences. 29: 390-2.
25. S. Maayan, V. Soskolne, D. Engelhard, et al. (1993). Sexual behavious of homosexual and bisexual men sttending an HIV testing clinic inJerusalem 1986/7-1990. Israel Journal of Psychiatry. 30: 15-18.
26. S. Pollack, Z. Bentwich, S. Maayan, M. Elkan, R. Raz, E. Simchen. (1993). Epidemiological and immunological study of HIV seropositive Ethiopian immigrants in Israel. Israel Journal of Medical Sciences. 29: 19-23,
27. S. Maayan, E. Shinar, M. Aefani, S. Soughayer, N. Manny. (1993). HIV/AIDS among Palestinian arabs. Israel Journal of Medical Sciences. 29:7-10,
28. I. Yust, S. Maayan, M. Burke, N. Vardinon, A. Moses, et al. (1993). Clinical, epidemiological and natural history study of HIV-1 infection among seropositive homo/bisexuals in Israel 1986-1992. Israel Journal of Medical Sciences. 29: 15-18
29. V. Soskolne, S. Maayan, N. Dormoi. (1993). Sexual behaviour of heterosexual men and women attending an HIV testing clinic. Israel Journal of Medical Sciences. 29: 37-40.
30. S. Maayan, E. Shufman, D. Engelhard, D. Shuval. (1994). Exposure to Hepatitis B, C and HTLV among Israeli drug abusers in Jerusalem. Addiction. 89:869-74,
31. S. Maayan, E. Shinar, M. Aefani, S. Soughayar et al. (1994). HIV-1 Incidence among Israeli and Palestinian blood donors. AIDS. 8: 133-34, 1994 .
32. C. Pederson, Barton , A. Chiesi, C. Katlama, S. Maayan. (1995). HIV related non-Hodgkin's lymphoma among European AIDS patients. Europ J Hematology. 55:245-250.
33. B. Kanishkowy, R. Edmon, S. Maayan. (1996). HIV care for Ethiopian immigrants in an Israeli family practice. Family Systems Health. 14:73-81.
34. A. Moses, S. Maayan, G. Rahav, et al. (1996). HIV infection and AIDS patients in Jerusalem, a microcosm of AIDS in Israel. Israel Journal of Medical Sciences.32:716-721.
35. S. Gehring, S. Maayan*, H. Ruppach, P. Balpe, I. Yust, A. Rimlawi, Z. Bentwich, V. Dietrich. (1997). Molecular Epidemiology of HIV1 in Israel. Journal of AIDS. 15: 296-303
36. M. Schlesinger, R. Rabinowitz, P. Levy, S. Maayan. (1996). The expression of CD8 on B lymphocyted in HIV infected individuals. Immunology letters. 50: 23-27,
37. S. Maayan, N. Marks, A. Viterbo, A. Morag, M. Shapiro. (1997). HIV infection and susceptibility to epidemic bacterial infection among Rwandan refugees. Int J. Infect Diseases.
38. S.N. Heyman, Y. Ginosar, M. Shapiro, S. Maayan. (1997). Diarrheal epidemics among Rwandan refugees, 1994; Managementt and outcome in a field hospital.
J. Clinical Gastro. 25: 595-601.
39. S.N. Heyman, Y. Ginosar, L. Niel, Y. Amir, M. Shapiro, S. Maayan. (1998). Meningococcal meningitis among Rwandan refugees: Diagnosis, management and outcome in a field hospital, Goma 1994. Int J. Infect. Dis. 2: 137-142
40. V. Soskolne, S. Maayan. (1998). Factor associated with non-use of condom in heterosexual men and women attending an HIV testing clinic in Israel. Public Health Reviews. 26: 175-187 .
41. V. Soskolne, S. Maayan. (1998), HIV knowledge, beliefs and sexual behaviour of heterosexual drug abusers and non drug abusers attending an HIV testing clinic in Israel. Israel Journal of Psychiatry. 35: 307-317 .
42. M. Miller, A. Ahiron, M. Shaklai, Maayan S, B. Shohat. (1998). Ethnic cluster of HTLV1 infection in Israel among the Mashadi Jewish population. J. Med. Virology. 56: 269-274.
43. S. Maayan, L. Zhang, E. Shinar, J. Ho, N. Manni, L.G. Kostrikis, A.V. Neumann. (2000). Evidence for recent selection of the CCR5 - Delta 32 deletion from differences in it’s frequency between askenazi & sepharadi Jews. Genes and Immunity. 1: 358-61.
44. Grossman Z PI, Vardinon NC, Chemtob DC, Alkan MLC, Bentwich ZC, Levi IC, Maayan S PI, Schapiro JM PI. (2001). Genotypic variation of HIV-1 reverse transcriptase and protease: comparative analysis of clade C and clade B. AIDS. Aug17;15(12):1453-60 .
45. Shapira-Nahor O PI, Maayan S PI, Peden KWC, Rabinowitz RC, Schlesinger MC, Alian A,. (2002). Panet A PI.Replication of HIV-1 deleted Nef mutants in chronically immune activated human T lymphocyte cells. Virology. Nov 10;303(1):138-45.
46. Wolday D PI, Maayan S PI, Mariam ZGC, Berhe NC, Seboxa TC, Britton SC, Galai NC, Landay AC, Bentwich Z PI. (2002). Treatment of intestinal worms is associated with decreased HIV plasma viral load. J Acquir Immune Defic Syndr. Sep 1;31(1):56-62 .
47. Loemba H PI, Brenner BC, Parniak MAC, Maayan SC, Spira BT , Oliveira M, Essex MC, Wainberg MA PI. (2002). Co-receptor usage and HIV-1 intra-clade C polymorphisms in the protease and reverse transcriptase genes of HIV-1 isolates from Ethiopia and Botswana. Antivir Ther. Jun;7(2):141-8.
48. Enk C PI, Entebby I PI, Abramson NC, Greenberg ZC, Maayan SPI , Marva EC , Strauss UC , Benezra DC. (2003). Onchocerciasis among |Ethiopian immigrants in Israel. I M A J. 5:485-8
49. Harris ME PI, Maayan S PI, Kim BC, Zeira M, C Ferrari GC, Birx DLC, McCutchan FE PI. (2003). A cluster of HIV type 1 subtype C sequences from Ethiopia, observed in full genome analysis, is not sustained in subgenomic regions .AIDS Res Hum Retroviruses. Dec; 19(12): 1125-33.
50. Wolday D PI, Gebremariam ZC, Mohammed ZC, Dorigo-Zetsma WT, Messele TT, Geyid AC, Sanders EC, Maayan S PI. (2004). The impact of syndromic treatment of sexually transmitted diseases on genital shedding of HIV-1. AIDS. Mar 26;18(5):781-5.
51. Grossman Z PI, Paxinos EEC, Averbuch DC, Maayan SC, Engelhard DC, Lorber MC, Istomin VC, Shaked YC, Mendelson EC, Schapiro JM. C. (2004). Mutation D30N is not preferentially selected by subtype C HIV-1 in the development of resistance to Nelfinavir. Antimicrob Agents Chemother. Jun;48(6):2159-65.
52. Turner DC, Brenner BC, Moisi DC, Detorio M , Cesaire R, Kurimura TC, Mori H, Essex MC , Maayan SC, Wainberg MA PI. (2004). Nucleotide and amino acid polymorphisms at drug resistance sites in non-B-subtype variants of human immunodeficiency virus type 1 Antimicrob Agents Chemother. Aug;48(8):2993-8.
53. Ferrari G PI,, Currier JRC, Harris ME, C Finkelstein SC, de Oliveira AT, Barkhan DC, Cox JHC, Zeira MC, Weinhold KJC, Reinsmoen NC, McCutchan FC, Birx DLC, Osmanov SC, Maayan S PI. (2004). HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians.Hum Immunol. Jun;65(6):648-59.
54. Wolday D PI, Zeru G/MariamC , Mohammed ZC, Sanders EC, Geyid AC, Maayan S PI. (2004). Risk factors associated with treatment failure of sexually transmitted diseases among women seeking primary care in Addis Ababa. Sex Transm Infect. Oct;80(5):392-4.
55. Grossman Z PI , Lorber M PI , S. Maayan PI , Levi IC, ChowersC MC , Sthoeger Z, FC. SchlaefferC, Z. KraOz, C J.M. Schapiro KC. Riesenberg. PI .(2005) Drug-resistant HIV among drug-naïve patients in Israel .Clinical Infectious Diseases. Jan.(40);294-302 .
56. Currier J PI, Cox JC, Ferrari G C, Maayan S PI , Birx.DC . (2005) Immunodominance and cross-reactivity of B5703 restricted CD8 T lymphocytes from HIV-1 subtype C infected Ethiopians AIDS Research and Human Retroviruses ;21(3):239-45.
57. Mocroft A PI, Oancea CC, Van Lunzen JC, Vinogradova E, C Chiesi A, C Maayan SC, Phillips AC, Lundgren JC. (2005) Decline in Esophageal Candidiasis and use of antimicotics in European patients with HIV. Am J Gastroenterol :100:1446-1454
58. Adal M, Ayele W, Wolday D, Messele T, Berkhout B, Maayan S, Pollakis G, Dorigo-Zetsma W. Evidence of genetic variability of human immunodeficiency virus type 1 in plasma and cervicovaginal lavage in ethiopian women seeking care for sexually transmitted infections.AIDS Res Hum Retroviruses. 2005 Jul;21(7):649-53.
Clinical Observations (Case reports)
1. P.S. Farkas, S. Maayan, A.A. Bloom. (1981). Markedly elevated creatine phosphokinase, cotton wool spots and pericarditis in a patients with leptospirosis. Gastroenterology. 80:587.
2. E. Perla, S. Maayan, S.N. Miller, et al. (1985). Disseminated cryptococcosis presenting as the adult respiratory distress syndrome. New York State Journal of Medicine. 85: 740-46 .
3. Y. Kleinman, Y. Yust, S. Maayan, D. Rave, et al. (1986). Transmission of Acquired immunodeficiency Syndrme (AIDS) by a blood transfusion given in 1979 in Israel. Israel Journal of Medical Sciences. 22: 404-7 .
4. Z. Ackerman, R. Or, S. Maayan, S. Slavin. (1986). Cerebral Toxoplasmosis following bone marrow transplantation. Israel Journal of Medical Science; 22:582-85
5. S. Maayan, H.P. Wormser, J. Widerhorn, E.R. Sy et al. (1987). Strongyloides sterocoralis hyperinfection in a patient with acquired immunodeficiency syndrome. American Journal of Medicine. 83:945-948.
6. M. Ephros, D. Engelhard, A. Avital, I. Yatsiv, S. Maayan, H. Bercovier. (1989). Legionella Gormanii pneumonia in a child with Chronic granulomatous disease. Pediatiric Infectious Diseases. 8: 726-7 .
7. D. Meirow, A. Moses, S. Maayan, J.G. Shenkar. (1989). Chronic tuboovarian abscess due to staph. aureus: a case report and literature review. Eur J Obstet Gynocol Repro Biology. 33(3):275-279 .
8. S. Maayan, V. Meiner, D. Engelhard. (1991). Tuberculosis and the Acquired Immune Deficiency Syndrome. Israel Journal of Medical Sciences. 27: 576-77
G. Rahav, S. Maayan. (1992). Nail pigmentation associated with Zidovudine. Scandinavian J Infect Dis. 24:557-59 .
10. K. Marks, Y. Amitai, D. Engelhard, M. Kori, S. Maayan. (1993). Mycobacterium Bovis Lymphadenitis complicating BCG vaccination in an infant with symptomatic HIV infection. Israel Journal of Medical Sciences. 29: 381-82 .
11. D. Gillis, S, Klaus, LF Schnur, D. Engelhard, S. Maayan. (1995). Diffusely disseminated cutaneus Leishmaniasis in a child with AIDS. Ped Inf Disease. 14(3):247-249 .
12. Y. Shoshan, S. Maayan. (1996). Chronic subdural empyema a new presentation of neurobrucellosis. Clinical Infections Diseases. 23(2): 400-401.
13. A. Moses, G. Rahav, A-J Bloom, A. Polliack, S. Maayan. (1995). Primary lymphoma of the esophagus in a patient with AIDS. J. Clin. Gastroenterology. 21(4): 327-328 .
Letters
1. J. Casey, S. Maayan. (1981). Bacteremic patient as a source of infection. New England Journal of Medicine. 305: 582 (27.766; 1/100).
2. R. Singer, Y. Amitai, S. Maayan, S. Shimonovitz, M. Geist. (1991). Neonatal Brucellosis, An unusual mode of transmission. Lancet. 338: 127-28 (16.135; 2/100; 5).
3. A. Moses, I. Hardan, E. Shinar, D. Engelhard, S. Maayan. (1991). Clostridium Septicum facial cellulitis. Reviews of Infectious Diseases; 13(3):525-27.
4. A. Kalinkovich, S. Maayan, Z. Wiesman, N. Harpaz, Z. Bentwich. (1994). Immune activiation, a cofactor for HIV transmission in Thailand? Lancet. 343: 1506-7, (16.135; 2/100; 4).
Reviews, Editorials
1. S. Maayan, Z. Handzel. (1993). Editorial: AIDS in Israel 1993. Israel Jouranl Medical Sciences; 29(S): 1-2, (0.508; 53/100; 2;1).
2. G. Rahav, S. Maayan. (1993). Nucleoside analogues in the treatment of AIDS. Harefuah הרפואה - 125: 272-80, ( In Hebrew).
3. S. Maayan. (1998). Antiretroviral drugs: The new era in the AIDS therapeutics - A review. Harefuah הרפואה; 134: 190-193.
4. O. Elishoov, M. Schwaber, S. Maayan, et al. (1995). Nontropical pyomiositis in immunocopetent hosts - A reveiw. Inf Dis in Clin Practice;4:17-20, (0.289; 31/34; -).
5. Review on a book : S.Maayan. Global AIDS Myths and Facts by A. Irwin, J. Millen, D.Fallows. (2005) CID , in press.