Head, Department of Hematology
Hadassah University Hospital
Ein-Karem, Jerusalem.
Prof. Dina Ben-Yehuda was born in (Haifa) Israel in 1953.
She received her medical degree from the Ben-Gurion University Medical School (1974-1980).
She then continued her medical training as an intern and resident at Hadassah University Hospital (1981-1985) specializing in Hematology. Her training in basic research started at the Hebrew University Medical School and the Lautenberg Center for Immunology at the Hebrew University and was completed at the Sloan Kettering Institute for Cancer Research in New York (1990-1992).
Since returning to Israel, Professor Ben-Yehuda has set up her own laboratory which does both molecular diagnostics of hematologic diseases and basic research.
In April 2000, Professor Ben-Yehuda was appointed to be the Director of the Hematology Department in Hadassah University Hospital.
Prof. Ben-Yehuda is extensively involved in clinical work as well as research and teaching and was awarded prizes for outstanding teacher in the Faculty of Medicine since 1984.
She participates in world-wide clinical trials and is well recognized in her international activities in the scientific community (guest lecturer, member of medical societies, member of editorial boards).
List of Publications
(updated October 2004)
Original articles
1. Steiner D. Neurological findings in patients with adult type Gaucher disease. MD thesis. Ben-Gurion University Press, 1982.
2. Pode D., Perelberg S., and Steiner D. Busulphan induced hemorrhagic cystitis. J. Urol. 130:347-348, 1983.
3. Slavin S., Naparstek E., Weshler Z., Brautbar C., Rachmilewitz E.A., Fuks Z., Elias M., Steiner-Salz D., Shinar E. Bone marrow transplantation for severe aplastic anemia in HLA-identical siblings using TLI and cyclophosphamide. Transplant. Proc. 15:668-670, 1983.
4. Cnaani E., Gale R.P., Steiner D., Aghai E., Berrebi A., and Januszewics E. Altered transcription of an oncogene in chronic myelocytic leukemia. Lancet 8377(1):593-595, 1984.
5. Steiner-Salz D., Yahalom Y.N., and Polliack A. Non-Hodgkin's lymphoma associated with pregnancy. Cancer 56:2087-2091, 1985.
6. Knobler H.Y., Sagher U., Peled I.J., Wexler M.R., Steiner-Salz D., Rubinstein N., Weshler Z., Or R., and Slavin S. Tolerance to donor-type skin in the recipient of bone marrow allograft. Transplantation 40:223-225, 1985.
7. Slavin S., Or R., Wiess L., Cividalli G., Steiner-Salz D., Samuel S., Galili N., Olsschwang D., Hale G., and Waldmann H. The use of monoclonal rat antihuman lymphocyte antibody (CAMPATH-1) for prevention of GVH disease in man. Adv. Exp. Med. 86:813-818, 1985.
8. Slavin S., Waldmann H., Or R., Cividalli G., Naparstek E., Steiner-Salz D., Michaeli J., Galun E., Wiess L., Samuel S., Moprecki S., Bar S., Brautbar C., Hale G., Rachmilewitz E.A., and Reisner Y. Prevention of graft versus host disease in allogeneic bone marrow transplantation for leukemia by T-cell depletion in vitro prior to transplantation. Trans. Proc. 17:465-467, 1985.
9. Ben-Yehuda A., Heyman A., and Steiner-Salz D. False positive reaction for urinary ketones with mesna. Drug Inteligece and Clinical Pharmacy. 21:547-548, 1987.
10. Stalnikowicz R., Eliakim R., Steiner-Salz D., Gross D., and Okon E. Should carcinoid tumors associated with pernicious anemia be treated aggressively? J. Clin. Gastroenterol. 9 (5):521-525, 1987.
11. Shir Y., Ben-Yehuda D., Polliack A., and Magora F. Prolonged continuous epidural methadone analgesia in the treatment of back and pelvic pain due to multiple myeloma. Pain Clinic 1:255-258, 1988.
12. Ben-Yehuda D., Rose M., Michaeli J., and Eldor A. Permanent neurological complications in patients with thrombotic thrombocytopenic purpura. American J. of Hematol. 29:74-78, 1989.
13. Ben-Yehuda D., Ben- Yehuda A., Yarom N., Polliack A., and Okon E. Syncytial variant of nodular sclerosing Hodgkin's disease- A new clinical pathological entity. Cancer. 65(5):1167-1172, 1990.
14. Shapira S.C., Ben-Yehuda D., Landsberg G., and Magora F. Epidural administration of drugs for pain relief in patients on low dose aspirin. Pain Clinic 4:231-2334, 1991.
15. Shapira S.C., Ben-Yehuda D., Landsberg G., and Magora F. Epidural injection during treatment with aspirin and other non-steroidal anti-inflammatory drugs-A protocol. Harefuah. 121(7-8):254-255, 1991.
16. Eldor A., Moser A., Rose M., Ben-Yehuda D., and Rachmilewitz E.A. Thrombotic Thrombocytopenic Purpura: The Israeli Experience. Transfus. Sci. 13:53-57, 1992.
17. Eldor A., Gillis S., and Ben-Yehuda D. The response to treatment in chronic ITP. South. Asian. J. Trop. Med. Pub. Hlt. 14: 43-47, 1992.
18. en-Yehuda D., Gillis S., and Eldor A. Clinical and therapeutic experience in 712 Israeli patients with ITP. Acta Hematol. 91:1-5, 1994.
19. Ben-Yehuda D., Houldsworth J., Parsa N.Z., and Chaganti R.S.K. Gene amplification in Non-Hodgkin's Lymphoma. Brit. J. of Hematology. 86:792-797, 1994.
20. Zion M., Ben-Yehuda D., Avraham A., Cohen O., Wetzler M., Melloul D. and Ben-Neriah Y. Progressive de novo DNA methylation at the bcr/abl locus in the course of Chronic Myelogenous Leukemia. Proc. Natl. Acad. Sci. 91:10722-10726, 1994.
21. Caspi O., Polliak A., Klar R. and Ben-Yehuda D. The relationship between inflammatory bowel disease and leukemia-is it just coincidence? Leukemia and Lymphoma. 17:255-262, 1995.
22. Abeliovich D., Yehuda O., Krichevsky S., Ben-Neriah S., Ludkovsky O., Nagler A., and Ben-Yehuda D. "Reversed" bcr/abl rearrangement detected by FISH in Philadelphia negative chronic myelocytic leukemia. Cancer Genet. Cytogenet. 81:115-117, 1995.
23. Zamir O., Szold A., Deutsch I., Matzner Y., Ben-Yehuda D., and Freund H.R. Laparoscopic splensctomy for immune thrombocytopenic purpura. Harefuah 128 (9):539-541, 1995.
24. Gillis S., Sofer O., Dan E., Zelig O., Ben-Yehuda D., Isackson R., Ben-Basat Rachmilewitz EA., and Polliack A. Secondary t(15;17) APL after treatment of Hodgkin's disease. Annals of Oncology, 6:777-779, 1995.
25. Abeliovich D., Yehuda O., Ben-Neriah S., Kapelushnik Y. and Ben-Yehuda D. Inv dup(10) lacking -satellite DNA in bone marrow cells of a patient with acute myeloid leukemia.a Cancer Genet. Cytogenet. 89:1-6, 1996.
26. Ben-Yehuda D., Polliack A., Okon E., Sherman Y., Fields S., Lebenshart P., Lotan C. and Libson E. Image-Guided Core Needle Biopsy in Malignant Lymphoma: Experience with 100 Patients Suggesting the Technique is Reliable. J. Clin. Oncol. 14:2431-2434, 1996.
27. Ben-Yehuda D., Krichevsky S., Caspi O., Rund D., Polliack A., Abeliovitch D., Zelig O., Paltiel O., Or R., Peretz T., Ben-Neriah S., Yehuda O., and Rachmilewitz E. A. P53 mutations and microsatellite instability in therapy related leukemia suggests mutator phenotype. Blood, 88(11):4296-4303, 1996.
28. Zamir O., Szold A., Deutsch I., Matzner Y., Ben-Yehuda D., Seror D., Deutsch I., and Freund H.R. Laparoscopic splensctomy for immune thrombocytopenic purpura. J. of Laparoendoscopic Surgery, 6:301-304, 1996.
29. Mori N., Takeuchi S., Tasaka T., Lee S., Spira S., Ben-Yehuda D, Mizoguchi H, Schiller G., Koeffler HP. Absence of microsatellite instability during the pogression of chronic myelocytic leukemia. Leukemia 11:151-152, 1997.
30. Tam W., Ben-Yehuda D., Hayward WS. bic, a novel gene activated by proviral insertions in ALV-induced lymphomas, is likely to function through its non-coding RNA. Molecular and Cellular Biology 17:1490-1502,1997.
31. Palumbo G.A., Yarom N., Gasit A., Sandelon Z., Baniash M., Levitzki A., Ben-Yehuda D. A tyrphostin (AG17) induces apoptosis and inhibition of CDK2 activity in a lymphoma cell line which overexpresses bcl2. Cancer Research 57(12):2434-2439, 1997.
32. Mori N., Morosetti R., Lee S., Spira S., Ben-Yehuda D., Schiller G., Landolfi R., Mizoguchi H., Koeffler HP. Allelotype analysis in the evolution of chronic myelocytic leukemia. Blood 90:2010-2014, 1997.
33. Ben-Yehuda D. Microsatellite instability analysis in human leukemia, Reviews in Clinical and Experimantal Hematology, 3:71-79, 1997.
34. Ben-Yehuda D., Krichevsky S., Rachmilewitz E.A, Avraham A., Palumbo G. A., Frassoni F., Sahar D., Rosenbaum H., Paltiel O., Zion M., Ben-Neriah Y. Monitoring disease progression and interferon therapy in CML by abl promoter methylation.Blood, 90:4918-4923, 1997.
35. Lossos IS., Bogomolsky-Yahalome V., Yehuda O., Ben-Neriah S., Ben-Yehuda D., Leizerowitz R., Polliack A. A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia. Cancer Genetics and Cytogenetics. 106(1):78-79, 1998.
36. Segel, M.J., Paltiel, O., Zimran, A., Gottschalk-Sabag, S., Schibi, G., Krichevski, S., Ludkovski, O., Ben-Yehuda, D. Geographic variance in the frequency of the t(14;18) translocation in follicular lymphoma: An Israeli Series Compared to the World Literature. Blood Cell Molecules and Diseases. 24(4):62-72, 1998
37. Meirow D, Ben Yehuda D, Prus D, Poliack A, Schenker JG, Rachmilewitz EA, Lewin A. Ovarian tissue banking in patients with Hodgkin's disease: is it safe? Fertil Steril. 69(6):996-998, 1998
38. Mori N., Morosetti R., Spira S., Lee S., Ben-Yehuda D., Schiller G., Landolfi R., Mizoguchi H., Koeffler HP. Chromosome band 1p36 contains a putative tumor suppressor gene important in the evolution of CML. Blood, 92(9):3405-3409, 1998.
39. Gafanovich A., Ramue N., Krichevsky S., Peer Y., and Ben-Yehuda D. Microsatellite instability and p53 mutations in secondary pediatric neoplasms. Cancer. 85:504-510, 1999.
40. Raanani P., Shpilberg O., Gillis S., Avigdor A., Hardan I., Berkowicz M., Sofer O., Lossos I., Chetrit A., Ben-Yehuda D., and Ben-Bassat I. Salvage therapy of refractory and relapsed acute leukemia with high dose mitoxantrone and high dose cytarabine. Leukemia Research, 23:695-700, 1999.
41. Asimakopoulos FA., Shteper PJ., Fibach E., Rachmilewitz E., Ben-Neriah Y., Ben-Yehuda D. Prognostic significance of c-ABL methylation in chronic myelogenous leukemia:still an open question Blood ,1;94(3):1141, 1999.
42. Asimakopoulos A.A., Shteper P.J., Krichevsky S., Fibach E., Polliack A., Rachmilewitz E., Ben-Neriah Y., and Ben-Yehuda D. C-abl methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia. Blood, 94:2452-2460, 1999.
43. Yehuda O, Abeliovich D, Ben-Neriah S, Sverdlin I, Cohen R, Varadi G, Orr R, Ashkenazi YJ, Heyd J, Lugassi G, Ben-Yehuda D. Clinical implications of fluorescence in situ hybridization analysis in 13 chronic myeloid leukemia cases: Ph-negative and variant Ph-positive. Cancer Genet Cytogenet 114(2):100-7, 1999
44. Hirshberg B., Souval D., Fibach E., Friedman G., Ben-Yehuda D. Flow cytometric analysis of autonomous growth of erythroid precursors in liquid culture detects occult polcthemia vera in the Budd-Chiari syndrome. J Hepatol. 32(4):574-8, 2000
45. Paltiel O., Schmit T., Adler B., Rachmilewitz E.A., Polliack A., Cohen A., Haim N., Ben-Shachar M., Epelbaum R., Barchana M., Cohen R., Ben-Yehuda D. The incidence of lymphoma in first degree relatives of patients with Hodgkin's disease and non-Hodgkin's lymphoma-a registry linked study. Cancer 15;88(10):2357-66, 2000
46. Paltiel O, Zelenetz A, Sverdlin I, Gordon L, Ben-Yehuda D. Translocation t(14;18) in healthy individuals: Preliminary study of its association with family history and agricultural exposure. Annals of Oncology 11 (Supp.1):75-80, 2000
47. Sklair-Levy M, Polliack A, Shaham D, Applbaum YH, Gillis S, Ben-Yehuda D, Sherman Y, Libson E. CT-guided core-needle biopsy in the diagnosis ofmediastinal lymphoma. Eur Radiol 10(5):714-8, 2000
48. Ben Yehuda A, Globerson A, Krichevsky S, Bar On H, Kidron M, Friedlander Y, Friedman G, Ben Yehuda D. Ageing and the mismatch repair system. Mech Ageing Dev. 20;121(1-3):173-9, 2000
49. Peylan-Ramu N, Diment J, Krichevsky S, Ben-Yehuda D, Bhatia K, Magrath IT. Expression of EBV encoded nuclear small non-polyadenylated RNA (EBER) molecules in 32 cases of childhood Burkitt's lymphoma from Israel. Leuk Lymphoma 40(3-4):405-11, 2001
50. Shteper PJ, Siegfried Z, Asimakopoulos FA, Palumbo GA,Rachmilewitz EA, Ben-Neriah Y, Ben-Yehuda D. ABL1 methylation in Ph-positive ALL is exclusively associated with the P210 form of BCR-ABL Leukemia 15(4):575-82 2001
51. Da’as N, Polliack A, Gail A, Darmon D, Kleinman Y, Goldfarb AW, Ben-Yehuda D. Kidney involvement and renal manifestation in non-Hodgkin’s lymphoma and chronic lymphocytic leukemia: A retrospective study in 700 patients. European Journal of Haematology , 67:1-8, 2001
52. Shteper PJ and Ben-Yehuda D. Molecular evolution of chronic myeloid leukemia Seminars in Cancer Biology, 11:313-322, 2001
53. Ashhab Y, Alian A, Polliack A, Panet A and Ben-Yehuda D. Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern FEBS Letters 495:56-60, 2001.
54. Durst, R., Rund, D., Schurr, D., Eliav, O., Ben-Yehuda, D., Shpizen, S,., Ben-Avi, L., Schaap, R., Pelz, I. and Leitersdorf, E. One year experience with a low density lipoprotein apheresis system. IMAJ, 4: 677-680, 2002.
55. Shteper PJ, Ben Yehuda D. Methylation of gene promoters in leukemogenesis. IMAJ, 4: 1066-1071, 2002.
56. Boger-Megiddo I, Apter S, Spencer JA, Ben-Yehuda D, Nof E, Libson E. Is chest CT sufficient for follow-up of primary mediastinal B-cell lymphoma in remission? AJR Am J Roentgenol. Jan;178(1):165-7, 2002.
57. Alcalai R, Ben-Yehuda D, Ronen I. and Paltiel O. Ethnicity and Prognosis in Acute Myeloid Leukemia. Am J Hematol. 72: 127-134, 2003.
58. Agid R, Sklair-Levy M, Bloom Ai, Lieberman S, Polliack A, Ben-Yehuda D, Sherman Y. and Libson E. CT-guided Biopsy with Cutting-edge Needle for the Diagnosis of Malignant Lymphoma: Experience of 267 Biopsies. Clin Radiol 58: 143-147, 2003.
59. Shteper PJ, Zcharia E, Ashhab Y, Peretz T, Vlodavsky I and Ben-Yehuda D. Role of promoter methylation in regulation of the mammalian heparanase gene. Oncogene 22: 7737-7749, 2003.
60. Nachmias B, Ashhab Y, Bucholtz V, Drize O, Kadouri L, Lotem M, Peretz T, Mandelboim O and Ben-Yehuda D. Caspase-Mediated Cleavage Converts Livin from an Anti-apoptotic to a Pro-apoptotic Factor: Implications for Drug-resistant Melanoma. Cancer Research 63: 6340-6349, 2003.
61. Ekstein, D., Ben-Yehuda, D., Slyusarevsky, E., Lossos, A., Linetsky, E., Siegal, T. CSF Analysis of IgH Gene Rearrangement in CNS Lymphoma: Relationship to the Disease Course. Neurology. In Press.
62. Levitzki A. and Ben-Yehuda, D. From Tyrphostins to Iressa and Gleevec: Signal transduction therapy from concept to the patient bed. Chemical Probes in Biology 391-402, 2003.
63. Lieberman S, Libson E, Maly B, Lebensart P, Ben-Yehuda D and Bloom AI. Imaging-guided percutaneous splenic biopsy using a 20- or 22-guage cutting-edge core biopsy needle for the diagnosis of malignant lymphoma. Am J Roentgenol. 181(4): 1025-7, 2003.
64. Rund D and Ben-Yehuda, D. Therapy-related leukemia and myelodysplasia: evolving concepts of pathogenesis and treatment. Hematology 9(3): 179-87, 2004.
65. Lossos A., Ashhab Y.,Sverdlin E., Amir G., Ben-Yehuda, D. and Siegal T. Late-Delayed Cerebral Involvement in Systemic Non-Hodgkin Lymphoma: A Second Primary Tumor or a Tardy Relapse? Cancer 101(8): 1843-9, 2004.
66. Nachmias B., Ashhab Y. and Ben-Yehuda, D. The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer. Seminars in Cancer Biology 14: 231-243, 2004.
Case Reports
67. Steiner D., Eldor A., Vangrover D., Okon E., Ben-Chetrit E., Rachmilewitz E.A., Polliack A. Disseminated intravascular coagulation in two patients with histiocytic medullary reticulosis Am. J. Clin. Pathol. 82:119-123, 1984.
68 Levy-Lehad E., Steiner-Salz D., Berkman N., and Leitersdorf E. Reversible functional asplenia and subcapsular liver hematoma-two distinctive manifestations of amyloidosis. Klinische Wochenschrift. 65:1104-1107, 1987.
69. Ben-Yehuda A., Ben-Yehuda D., Libson E., and Polliack A. Plasmacytoma of the breast unusual initial presentation of myeloma. Blut. 58:169-170, 1989.
70. Ben-Yehuda A., Ben-Yehuda D., Or R., Landau E.H. and Krauz M. intestinal obstruction caused by bezoar: A rare complication after BMT. Transplantation 4:137-138, 1989.
71. Arber N., Breuer R., Berkman N., Okon E., and Ben-Yehuda D. Unresolved pneumonia due to endobronchial lipoma and actinomycosis. European Respiratory Journal. 2: 794-796, 1989.
72. Ben-Yehuda A., Ben-Yehuda D., Bneuer R. Atypical presentation of pneumocystis carinii pneumonia. Isr. J. Med. Sci. 26(10):568-569, 1990.
73. Almog Y., and Ben-Yehuda D. Epidural spinal cord infiltration: A complication of acute myeloblastic leukemia. Leukemia and Lymphoma. 4(2):149-151,1990.
74. Oren R., Schnur L.F., Ben-Yehuda D., Mayner V., Okon E., and Rachmilewitz E.A. Visceral Leishmaniasis: A difficult diagnosis and unusual causative agent. J. Infec. dis. 164(4): 746-749, 1991.
75. Lustman J., Ben-Yehuda D., Somer M., and Ulmansky M. Gaucher's disease affecting the mandible and maxilla. Int. j. Oral Maxillafac. Surg. 20(1):7-8, 1991.
76. Engelhard D., Eldor A., Polacheck I., Hardan I., Ben-Yehuda D., Amsalem S., Salkin I.F., Lopez-Berenstein G., Sacks T., Rachmilewitz E.A., and Barenholtz Y. Disseminated visceral fusariosis treated with amphotericin B-phospholid complex. Leukemia and Lymphoma 9:385-392, 1992.
77. Urbach H., Ben-Yehuda A., Ben-Yehuda D., Manor D., Naparstek Y. Successful treatment of pure red cell aplasia in SLE with erythropoietin. J Rheumatol. 22:2166-2169, 1995.
78. Zelig O., Goldin E., Okon E., Or R., Alian H., Kaspi O., and Ben-Yehuda D. Hepatobiliary graft versus host disease manifested by common and hepatic biliary ducts obstruction. Digestion, 58:494-497, 1997.
79. Da’as N., Lossos I.S., Yahalom V., Rund D.,Wolf D.G., Zelig O., Ben-Yehuda D. Candida Abscess of the Thyroid in a Patient with Acute Lymphatic Leukemia. European J. of Med. Res. 2:365-366,1997.
80. Hirshberg B, Kramer MR, Lotem M, Barak V, Shustin L, Amir G, Ben-Yehuda D, Ben-Yehuda A. Chronic eosinophilic pneumonia associated with cutaneous T-cell lymphoma. Am J Hematol 60(2):143-147, 1999.
81. Lossos IS, Ben-Yehuda D. Cutaneous and subcutaneous necrosis following dexrazoxane-CHOP therapy. Ann Pharmacother 33(2):253-254, 1999.
82. Gural A., Gillis S., Gafanovich A., Israel Z., Pomeranz S., Ben-Yehuda D. Massive intracranial bleeding requiring emergency splenectomy in a patient with CMV-associated thrombocytopenia. Haemostasis, 28:250-256, 1999.
83. Cohen Y., Libster D., Amir G., Hiller N., Da’as N., Ben-Yehuda D. and Polliack A. Primary ALK Positive Anaplastic Large Cell Lymphoma of the Pancreas. Leukemia & Lymphoma 44: 205-207, 2003.
84. Goldschmidt N, Gural A. and Ben-Yehuda D. Extensive Splenic Infarction, Deep Vein Thrombosis and Pulmonary Emboli Complicating Induction Therapy with All-trans-retinoic Acid (ATRA) for Acute Promyelocytic Leukemia. Leukemia & Lymphoma 44: 1433-1437, 2003
Chapters in Books/Book
85. Slavin S., Or R., Wiess L., Steiner-Salz D., Cividalli G., Brautbar C., Weshler Z., Galun E., Samuel S., Galili D., Ephros M., Shapiro M., Hale G., and Waldmann H. Elimination of graft versus host disease in matched allogeneic leukemic transplant recipients using CAMPATH-1. In: Microenvironments in the lymphoid system. (Klaus GGB, ed.) New-York, Plenum Press, 813-818, 1985.
86. Ben-Yehuda D., Ben-Neriah Y. Molecular Follow up of Chronic Myelocytic Leukemia, From the Chronic Phase to the Blast Crisis. In: Pre Malignancy and Tumor Dormancy. Editors: RH. Scheuermann and E. Yefenof. R.G. Landes Company Biomedical Publishers. 55-67, 1996.
87. Ben-Yehuda D. Anemia in Pregnancy In: Textbook of Obstetrics and Gynecology. Editors: Elchalal U, and Schenker JG. 599-608, 1998.
88. Ben-Yehuda D., Gershenzone L. Cancer in the House (Children-Book), publisher: Magazin Yam, 1999.